11 Result(s)
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Qisheng **n
Cell Culture
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Article
Open AccessDDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a significant public health issue. This study investigates the interplay...
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Open AccessHIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear...
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Open AccessThe kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled cell cycle progression and evasion from senescence. However, th...
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Open AccessScreening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, the development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) ...
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Establishment of two midgut cell lines from the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
Two cell lines were generated from larval midguts of Spodoptera frugiperda and have been 26 passaged over 50 times. The CT/BCIRL-SfMG1-0611-KZ line was established from 27 trypsinized, minced whole midgut tissues...
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Open AccessCaspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury
Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media and is associated with a significant high risk for severe renal failure and ...
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Open AccessInteraction of the primordial germ cell-specific protein C2EIP with PTCH2 directs differentiation of embryonic stem cells via HH signaling activation
Although many marker genes for germ cell differentiation have been identified, genes that specifically regulate primordial germ cell (PGC) generation are more difficult to determine. In the current study, we c...
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JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is crucial in chicken germ stem cell differentiation, but its role in the regulation of germ cell differentiation is unkno...
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The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene
NANOG is a transcription factor that functions in embryonic stem cells (ESCs) and a key factor in maintaining pluripotency. Here, we cloned the NANOG gene promoter from the Rugao yellow c...
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Regulatory mechanism of protein metabolic pathway during the differentiation process of chicken male germ cell
We explored the regulatory mechanism of protein metabolism during the differentiation process of chicken male germ cells and provide a basis for improving the induction system of embryonic stem cell differenti...
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Basing RNA-seq explored the regulatory mechanism of the carbohydrate metabolism pathways during chicken male germ cell differentiation
Our study aimed to explore the regulatory mechanism of the carbohydrate metabolism signaling pathways and related genes during the differentiation of chicken embryonic stem cells to male germ cells, providing ...
