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Open AccessIntegrated transcriptome and metabolome analysis reveals the molecular responses of Pardosa pseudoannulata to hypoxic environments
Terrestrial organisms are likely to face hypoxic stress during natural disasters such as floods or landslides, which can lead to inevitable hypoxic conditions for those commonly residing within soil. Pardosa pseu...
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Article
Open AccessCharacterization of the intestinal microbiota in MSM with HIV infection
HIV-infected persons demonstrate notable disturbances in their intestinal microbiota; however, the impact of intestinal microbiota on HIV susceptibility in men who have sex with men (MSM), as well as the effec...
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Article
lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells
Primordial germ cells (PGCs) are the ancestors of female and male germ cells. Recent studies have shown that long non-coding RNA (lncRNA) and histone methylation are key epigenetic factors affecting PGC format...
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Article
Open AccessDDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a significant public health issue. This study investigates the interplay...
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Article
Open AccessMap** the forage nitrogen, phosphorus, and potassium contents of alpine grasslands by integrating Sentinel-2 and Tiangong-2 data
Nitrogen (N), phosphorus (P), and potassium (K) contents are crucial quality indicators for forage in alpine natural grasslands and are closely related to plant growth and reproduction. One of the greatest cha...
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Article
Open AccessHIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear...
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Article
The urgent need to develop a new grassland map in China: based on the consistency and accuracy of ten land cover products
Grasslands are the most dominant terrestrial ecosystem in China, but few national grassland maps have been generated. The grassland resource map produced in the 1980s is widely used as background data, but it ...
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Article
Open AccessIsolation of Swine Bone Marrow Lin-/CD45-/CD133 + Cells and Cardio-protective Effects of its Exosomes
The identification in murine bone marrow (BM) of CD133 + /Lin-/CD45- cells, possessing several features of pluripotent stem cells, encouraged us to investigate if similar population of cells could be also isol...
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Article
iTRAQ-Based Comparative Proteomic Analysis Provides Insights into Tobacco Callus Response to Carbon Nanoparticles
Carbon nanomaterials (CNMs) have attracted a great deal of research interest for their potential application in plants. Some types of CNMs have exhibited the ability on regulating plant growth of plants, which...
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Article
Open AccessThe kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled cell cycle progression and evasion from senescence. However, th...
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Article
Open AccessStructural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction
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Open AccessGenome of the parasitoid wasp Cotesia chilonis sheds light on amino acid resource exploitation
A fundamental feature of parasitism is the nutritional exploitation of host organisms by their parasites. Parasitoid wasps lay eggs on arthropod hosts, exploiting them for nutrition to support larval developme...
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Article
Characteristics of the TDRD1 gene promoter in chickens
Tudor domain containing 1 (TDRD1) is a member of the TDRD family and plays an important role in embryogenesis and gametogenesis. A detailed study of the characteristics of chicken TDRD1 can lay a foundation fo...
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Sensor-Assisted Next-Generation Diagnostics: Emerging Concepts, Biomarkers, Technologies, and Challenges
The evolution of medical diagnosis has continued to broaden our understanding of diseases. The development of various omics technologies and the continuous advancement of medical sensor technology are pushing ...
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Chapter
Biocompatible Sensors Are Revolutionizing Healthcare Technologies
Sensors bridge the gap between disease diagnosis and the attainability of physiological indicators. The Internet of Things (IoT) and artificial intelligence algorithms have become the core of new-generation he...
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Article
Antibiotic Resistance Characterization of Bacteria Isolated from Traditional Chinese Paocai
In this work, the antibiotic resistance of 218 isolates to 9 different antibiotics was analyzed with minimum inhibitory concentration method. All Lactobacillus pentosus strains were found to be resistant to strep...
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Article
Open AccessScreening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, the development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) ...
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Article
Structure of SARS-CoV-2 main protease in the apo state
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Open Access20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation
Krüppel homolog 1 (Kr-h1) is a critical transcription factor for juvenile hormone (JH) signaling, known to play a key role in regulating metamorphosis and adult reproduction in insects. Kr-h1 can also be induc...
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Open AccessGenome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution
G-quadruplex (G4) structures have been predicted in the genomes of many organisms and proven to play regulatory roles in diverse cellular activities. However, there is little information on the evolutionary hi...