4 Result(s)
within
Qinglian Li
Life Sciences
-
Article
Semi-synthesis and structure-activity relationship study yield antibacterial vicenistatin derivatives with low cytotoxicity
Vicenistatin (1) is a 20-membered polyketide macrocyclic antibiotic with potent antimicrobial and cytotoxic activities. In this study, to further explore the potential of 1 as candidates of antibacterial drug dev...
-
Article
Open AccessUpregulation of a marine fungal biosynthetic gene cluster by an endobacterial symbiont
Fungal-bacterial associations are present in nature, playing important roles in ecological, evolutionary and medicinal processes. Here we report a fungus-bacterial symbiont from marine sediment. The bacterium ...
-
Article
The roles of genes associated with regulation, transportation, and macrocyclization in desotamide biosynthesis in Streptomyces scopuliridis SCSIO ZJ46
The deep-sea-derived microbe Streptomyces scopuliridis SCSIO ZJ46 produces desotamides A–D. Notably, desotamides A and B display antibacterial activities against pathogenic Gram-positive Streptococcus pneumoniae ...
-
Article
Open AccessCytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces
Antibiotic-producing microorganism can develop strategies to deal with self-toxicity. Cytorhodins X and Y, cosmomycins A and B, and iremycin, are produced as final products from a marine-derived Streptomyces sp. ...
