-
Article
Open AccessPINK1 ameliorates acute-on-chronic liver failure by inhibiting apoptosis through mTORC2/AKT signaling
Acute-on-chronic liver failure (ACLF) is a lethal syndrome with a remarkable short-term death rate. Even worse, effective internal medicine therapies are currently lacking. Increasing evidence indicates apopto...
-
Article
Open AccessFerroptosis in liver disease: new insights into disease mechanisms
Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel form of iron-dependent cell death, which is morphologically, genetically, and biochemically distinct from other well-...
-
Article
Open AccessPregnancy outcomes of patients with acute fatty liver of pregnancy: a case control study
Limited data exists regarding the pregnancy and infant outcomes of Acute Fatty Liver of Pregnancy (AFLP).
-
Article
Open AccessClinical characteristics of liver failure with hemophagocytic lymphohistiocytosis
Liver failure with hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome with high mortality. The aim of this study was to decipher clinical and laboratory characteristics of hemophagocytic l...
-
Article
Open AccessThe clinical parameters for the diagnosis of hepatitis B virus related acute-on-chronic liver failure with sepsis
It is still unknown that whether sepsis with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) fit into the conventional diagnostic criteria of sepsis. Our aim was to investigate the potentia...
-
Article
Open AccessClinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis
Stem cell therapy has been applied in the treatment of acute-on-chronic liver failure (ACLF). However, its clinical efficiency is still debatable. The aim of this systematic review and meta-analysis is to eval...
-
Article
Open AccessAn expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme
Proper regulation of neuronal gene expression is crucial for the development and differentiation of the central nervous system. The transcriptional repressor REST (repressor element-1 silencing transcription f...
-
Article
Open AccessCytokine levels contribute to the pathogenesis of minimal hepatic encephalopathy in patients with hepatocellular carcinoma via STAT3 activation
Hepatocellular carcinoma (HCC) patients were grouped according to the degree of encephalopathy, with healthy volunteers as controls. We investigated clinical presentation, protein and mRNA expression of 14 cyt...
