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Article
Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy
Antibodies as therapeutic agents are mostly used in oncology, as illustrated by their applications in lymphoma, breast cancer or colorectal cancer. This review provides a brief historical sketch of the develop...
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Article
Open AccessWnt/beta-catenin signaling in embryonic stem cell converted tumor cells
Embryonic stem cells (ESCs) are pluripotent stem cells and can form tumors containing cells from all three germ layers. Similarities between pluripotent stem cells and malignant tumor cells have been identifie...
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Article
Open AccessIntegrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. HCC has a poor prognosis associated with tumor recurrence and drug resistance, which has been attributed to the existence of hep...
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Article
Open AccessThe combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors
The clinical trials using immunotherapy have been performed for the treatment of variety of malignant tumors. However, large-scale meta-analysis of combined DC-CTL/CIK therapy on immune and clinical response i...
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Article
Open AccessMonitoring checkpoint inhibitors: predictive biomarkers in immunotherapy
Immunotherapy has become the fourth cancer therapy after surgery, chemotherapy, and radiotherapy. In particular, immune checkpoint inhibitors are proved to be unprecedentedly in increasing the overall survival...
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Article
Open AccessModified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor
Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either reg...
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Article
Open AccessCorrection: Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessChimeric antigen receptor T cells engineered to secrete CD40 agonist antibodies enhance antitumor efficacy
Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is limited. The combination of CAR-T cell therapy with ...
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Article
Open AccessAntitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4
The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development and antitumor acti...
