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Article
Open AccessClinical Application of Different Doses of Hydromorphone Slow-Release Analgesia in Lumbar Fusion in Elderly Patients
The aim of this study is to examine the analgesic efficacy of varying doses of hydromorphone hydrochloride in conjunction with absorbable gelatin sponge for postoperative pain management in elderly individuals...
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Article
WT1 gene mutations impact post-transplant relapse in myelodysplastic syndrome with excess blasts 2 patients
Wilms tumor 1 (WT1) gene mutations are infrequent in myelodysplastic syndrome (MDS), but MDS with WT1 mutations (WT1mut) is considered high risk for acute myeloid leukemia (AML) transformation. The influence of W...
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Article
Open AccessA single-cell transcriptomic study of heterogeneity in human embryonic tanycytes
Disruptions in energy homeostasis can lead to diseases like obesity and diabetes, affecting millions of people each year. Tanycytes, the adult stem cells in the hypothalamus, play crucial roles in assisting hy...
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Article
Open AccessJoint association of sedentary time and physical activity with abnormal heart rate recovery in young and middle-aged adults
Abnormal heart rate recovery (HRR), representing cardiac autonomic dysfunction, is an important predictor of cardiovascular disease. Prolonged sedentary time (ST) is associated with a slower HRR. However, it i...
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Article
A comparative study of software defect binomial classification prediction models based on machine learning
As information technology continues to advance, software applications are becoming increasingly critical. However, the growing size and complexity of software development can lead to serious flaws resulting in...
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Article
C*-basic construction between non-balanced quantum doubles
For finite groups X, G and the right G-action on X by group automorphisms, the non-balanced quantum double D(X; G) is defined as the crossed product (ℂXop)* ⋊ ℂG. We firstly prove that D(X; G) is a finite-dimensi...
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Article
Fe3O4@PANI composite improves biotransformation of waste activated sludge into medium-chain fatty acid
Core–shell structured Fe3O4@PANI composite was prepared using a chemical oxidation polymerization method and used as the bio-carrier to enhance the biotransformation of waste activated sludge to produce medium-c...
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Article
Evodiamine encapsulated by hyaluronic acid modified zeolitic imidazolate framework-8 for tumor targeted therapy
Evodiamine (EVO), a natural bioactive compound extracted from Evodia rutaecarpa, shows therapeutic ability against malignant melanoma. However, the poor solubility and bioavailability of EVO limit its clinical ap...
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Article
Open AccessApplication of citric acid can enhance the accuracy for 13C-urea breath tests in the diagnosis of Helicobacter pylori infection in Chinese patients
Previous published data have confirmed that the addition of a citric acid meal improves the accuracy of the 13C-urea breath test (13C-UBT). However, some studies have suggested that a citric acid test meal may no...
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Article
Open AccessBmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP
Retinoblastoma is one of the most common ocular malignancies in children. Bmi-1, a member of the Polycomb group family of transcriptional repressors, is expressed in a variety of tumors. The purpose of our stu...
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Article
Prophylactic therapy using epigenetic agents for RUNX1::RUNXT1-positive high-risk AML after Allo-HSCT
Disease recurrence is the leading cause of treatment failure in patients with RUNX1::RUNXT1-positive acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Post-tran...
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Article
Open AccessAssociations between a normal-range free thyroxine concentration and ovarian reserve in infertile women undergoing treatment via assisted reproductive technology
Some recent studies have shown that female subclinical hypothyroidism (SCH) is associated with diminished ovarian reserve (DOR). In this study, we aimed to investigate whether serum-free thyroxine (fT4) concen...
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Article
Farrerol Alleviates Diabetic Cardiomyopathy by Regulating AMPK-Mediated Cardiac Lipid Metabolic Pathways in Type 2 Diabetic Rats
Diabetic cardiomyopathy (DCM) is a prevalent complication of diabetes mellitus characterized by cardiac dysfunction and myocardial remodeling. Farrerol (FA), an active ingredient in Rhododendron with various p...
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Article
Preparation of Ni3S2 Electrocatalyst from Different Sulfur Sources and its Performance in Electrocatalytic Hydrogen Evolution Reaction
A series of Ni3S2 electrocatalysts were successfully prepared using nickel foam precursor as substrate and thiourea, sodium thiosulfate pentahydrate, sodium sulfide nonahydrate and sodium diethyldithiocarbamate a...
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Article
Open AccessFairer AI in ophthalmology via implicit fairness learning for mitigating sexism and ageism
The transformative role of artificial intelligence (AI) in various fields highlights the need for it to be both accurate and fair. Biased medical AI systems pose significant potential risks to achieving fair a...
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Article
Accurate nano-photonic device spectra calculation using data-driven methods
This study employed a data-driven approach involving the creation and training of a deep neural network model to swiftly compute spectral data for nano-photonic devices. Initially, the transfer matrix method w...
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Article
circ_0000337 Promotes the Progression of Cervical Cancer by miR-155-5p/RAB3B Axis
Current study aims to investigate the biological function of circular RNA (circRNA, circ_0000337) in cervical cancer (CC). Bioinformatic analyses were used to predict targets for circ_0000337 and miR-155-5p, a...
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Article
Persistence of soil microbial residuals and lignin phenols in forest ecosystems along the latitude gradient
Soil organic carbon (SOC) storage is mainly governed by inputs from plant and microbial sources. How the relative contributions of these two sources in forest soils vary along broad-scale environmental gradien...
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Article
Origin of the Chromospheric Umbral Waves in Sunspots
Oscillations are ubiquitous in sunspots and the associated higher atmospheres. However, it is still unclear whether these oscillations are driven by the external acoustic waves (p-modes) or generated by the in...
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Article
A Novel Homozygous RHOH Variant Associated with T Cell Dysfunction and Recurrent Opportunistic Infections
RHOH, an atypical small GTPase predominantly expressed in hematopoietic cells, plays a vital role in immune function. A deficiency in RHOH has been linked to epidermodysplasia verruciformis, lung disease, Burk...
