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Social Determinants of Physical Frailty
Social determinants of health encompass complex societal factors that can greatly impact individuals’ health and well-being across the lifespan. Among several proposed frameworks, the World Health Organization...
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Article
Navigating and diagnosing cognitive frailty in research and clinical domains
While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the c...
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Open AccessPredicting salivary cortisol and sexual behavior stigma among MSM in the American Men’s Internet Survey 2019
Physiological stress levels in response to sexual behavior stigma among men who have sex with men (MSM) in the United States (US) are understudied. The current study aims to explore the relationship between se...
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Open AccessInterseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older
Seasonal influenza causes significant morbidity and mortality with a disproportionately high disease burden in older adults. Strain-specific hemagglutination-inhibition (HAI) antibody titer is a well-establish...
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Open AccessSubstitution of self-reported measures for objectively assessed grip strength and slow walk in the Physical Frailty Phenotype: ramifications for validity
Frailty assessment promises to identify older adults at risk for adverse consequences following stressors and target interventions to improve health outcomes. The Physical Frailty Phenotype (PFP) is a widely-s...
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Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment
The reported primary dementia-protective benefits of angiotensin II type 1 receptor (AT1R) blockers (ARB) are believed, at least in part, to arise from systemic effects on blood pressure. However, there is a spec...
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Open AccessThe combined effects of physical frailty and cognitive impairment on emergency department- versus direct-admission hospitalizations
We aimed to study whether physical frailty and cognitive impairment (CI) increase the risk of recurrent hospitalizations in older adults, independent of comorbidity, and disability.
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Open AccessAgreement between standard and self-reported assessments of physical frailty syndrome and its components in a registry of community-dwelling older adults
The ability to identify frail older adults using a self-reported version of the physical frailty phenotype (PFP) that has been validated with the standard PFP could facilitate physical frailty detection in cli...
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Open AccessAging metrics incorporating cognitive and physical function capture mortality risk: results from two prospective cohort studies
Aging metrics incorporating cognitive and physical function are not fully understood, hampering their utility in research and clinical practice. This study aimed to determine the proportions of vulnerable pers...
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Open AccessThe Framingham risk score is associated with incident frailty, or is it?
Cardiovascular disease (CVD) risk factors are individually associated with frailty. This study examined whether Framingham CVD risk score (FRS) as an aggregate measure of CVD risk is associated with incident f...
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Open AccessSha** the next steps of research on frailty: challenges and opportunities
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Open AccessDevelo** a sensor-based mobile application for in-home frailty assessment: a qualitative study
Frailty syndrome disproportionately affects older people, including 15% of non-nursing home population, and is known to be a strong predictor of poor health outcomes. There is a growing interest in incorporati...
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The physical frailty syndrome as a transition from homeostatic symphony to cacophony
Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophys...
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Open AccessFrailty as an integrative marker of physiological vulnerability in the era of COVID-19
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The Longitudinal Association between Perceived Powerlessness and Sexual Risk Behaviors among Urban Youth: Mediating and Moderating Effects
A distal psychosocial factor, perceived powerlessness, has been found to predict various sexual risk behaviors among youth, yet no studies have assessed mediators or moderators in this relationship. Using a de...
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Integrating Frailty and Cognitive Phenotypes: Why, How, Now What?
This review elucidates the concept of frailty in relationship to reserve and resilience, the relationships and shared pathophysiology between physical frailty and cognitive impairment, the theoretical underpin...
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Impact of Experience Corps® Participation on Children’s Academic Achievement and School Behavior
This article reports on the impact of the Experience Corps® (EC) Baltimore program, an intergenerational, school-based program aimed at improving academic achievement and reducing disruptive school behavior in...
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Open AccessOlder adults’ perceptions and informational needs regarding frailty
Frailty has been recognized as an important medical syndrome in older adults. Growing literature supports the clinical application of frailty but US older adults’ perceptions of frailty have not been explored....
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Open AccessIncorporating prognosis in the care of older adults with multimorbidity: description and evaluation of a novel curriculum
Prognosis is a critical consideration in caring for older adults with multiple chronic conditions, or “multimorbidity”. Clinicians are not adequately trained in this area. We describe an innovative curriculum ...
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Impact of Experience Corps® Participation on School Climate
We examined the impact of the Experience Corps® (EC) program on school climate within Baltimore City public elementary schools. In this program, teams of older adult volunteers were placed in high intensity (>15 ...
