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  1. No Access

    Article

    Mammary duct luminal epithelium controls adipocyte thermogenic programme

    Sympathetic activation during cold exposure increases adipocyte thermogenesis via the expression of mitochondrial protein uncoupling protein 1 (UCP1)1. The propensity of adipocytes to express UCP1 is under a crit...

    Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson… in Nature (2023)

  2. Article

    Open Access

    Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

    Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that com...

    Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq… in Genome Medicine (2023)

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  3. Article

    Open Access

    NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice

    We recently showed that NOTUM, a liver-secreted Wnt inhibitor, can acutely promote browning of white adipose. We now report studies of chronic overexpression of NOTUM in liver indicating that it protects again...

    Fangfei Guo, Marcus Seldin, Miklós Péterfy, Sarada Charugundla… in Scientific Reports (2021)

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  4. No Access

    Article

    IDOL regulates systemic energy balance through control of neuronal VLDLR expression

    Liver X receptors limit cellular lipid uptake by stimulating the transcription of inducible degrader of the low-density lipoprotein receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors fo...

    Stephen D. Lee, Christina Priest, Mikael Bjursell, Jie Gao… in Nature Metabolism (2019)

  5. No Access

    Article

    Glass structure and crystallization in boro-alumino-silicate glasses containing rare earth and transition metal cations: a US-UK collaborative program

    Nuclear wastes generated from reprocessing of used nuclear fuel tend to contain a large fraction of rare earth (RE, e.g., Nd3+), transition (TM, e.g., Mo6+, Zr4+), alkali (A, e.g., Cs+), and alkaline earth cation...

    John S. McCloy, José Marcial, Deepak Patil, Muad Saleh, Mostafa Ahmadzadeh… in MRS Advances (2019)

  6. No Access

    Article

    Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA

    The conserved long noncoding RNA Me**s has anti-atherosclerotic effects in mice by acting with the nuclear hormone receptor LXR in macrophages to promote cholesterol efflux.

    Tamer Sallam, Marius Jones, Brandon J Thomas, **aohui Wu… in Nature Medicine (2018)

  7. No Access

    Article

    Prdm4 induction by the small molecule butein promotes white adipose tissue browning

    Microarray analysis of butein-treated adipocytes results in the identification of the PR domain containing 4 (Prdm4) transcription factor, which stimulates WAT browning and lipolysis and protects against diet-...

    No-Joon Song, Seri Choi, Prashant Rajbhandari, Seo-Hyuk Chang… in Nature Chemical Biology (2016)