8 Result(s)

Article

The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8

CHD8, a major autism gene, functions in chromatin remodelling and has various roles involving several biological pathways. Therefore, unsurprisingly, previous studies have shown that intellectual developmental di...

Alexander J. M. Dingemans, Kim M. G. Truijen, Sam van de Ven… in Translational Psychiatry (2022)

Article

Author Correction: Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei… in Nature Communications (2022)

Article

Schizophrenia polygenic risk is associated with child mental health problems through early childhood adversity: evidence for a gene–environment correlation

Previous studies have shown that schizophrenia polygenic risk predicts a multitude of mental health problems in the general population. Yet it is unclear by which mechanisms these associations arise. Here, we ...

Koen Bolhuis, Lisa R. Steenkamp… in European Child & Adolescent Psychiatry (2022)

Article

Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior

Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we...

Ronald de Vlaming, Eric A. W. Slob, Philip R. Jansen… in Communications Biology (2021)

Article

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

The phenotypic correlation between human intelligence and brain volume (BV) is considerable (r ≈ 0.40), and has been shown to be due to shared genetic factors. To further examine specific genetic factors driving ...

Philip R. Jansen, Mats Nagel, Kyoko Watanabe, Yongbin Wei… in Nature Communications (2020)

Article

Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample

Neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable and influenced by many single nucleotide polymorphisms (SNPs). SNPs ...

Arija G. Jansen, Gwen C. Dieleman, Philip R. Jansen, Frank C. Verhulst… in Behavior Genetics (2020)

Article

Genetic map** and evolutionary analysis of human-expanded cognitive networks

Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical ...

Yongbin Wei, Siemon C. de Lange, Lianne H. Scholtens… in Nature Communications (2019)

Article

Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Nat. Genet.; doi:10.1038/ng.3869; corrected online 31 May 2017 In the version of this article initially published online, heritability was misspelled in the penultimate sentence of the abstract. The error has ...

Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R Jansen… in Nature Genetics (2017)