40 Result(s)

Article

Correction: Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

The objective of this analysis is to evaluate the improvement in spinal pain with ixekizumab, placebo, and adalimumab based on objective measures of inflammation response in patients with ankylosing spondyliti...

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Effect size varies based on calculation method and may affect interpretation of treatment effect: an illustration using randomised clinical trials in osteoarthritis

To illustrate how (standardised) effect sizes (ES) vary based on calculation method and to provide considerations for improved reporting.

Thomas J. Schnitzer, Philip G. Conaghan, Francis Berenbaum… in Advances in Rheumatology (2024)

Article

Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials

The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive versus -negative patients with rheumatoid arthritis (RA). Four early RA abatacept trials ...

Kaleb Michaud, Philip G. Conaghan, Sang Hee Park… in Rheumatology and Therapy (2023)

Article

Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

This narrative review summarises the recommendations of a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) for the co...

Rebecca J. Moon, Jean-Yves Reginster, Nasser M. Al-Daghri… in Osteoporosis International (2023)

Article

Association between outpatient follow-up and incidence of revision after knee and hip replacements: a population-based cohort study

Follow-up visits 5 or 7 years after surgery were recommended for people having primary hip or knee replacement. The benefits of this practice to patients and the healthcare system, however, have not yet been s...

Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn… in BMC Musculoskeletal Disorders (2023)

Article

Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study

MRI bone surface area and femoral bone shape (B-score) measures have been employed as quantitative endpoints in DMOAD clinical trials. Computerized Tomography (CT) imaging is more commonly used for 3D visualiz...

Alan Brett, Michael A. Bowes, Philip G. Conaghan in BMC Musculoskeletal Disorders (2023)

Article

Prediction of flare following remission and treatment withdrawal in early rheumatoid arthritis: post hoc analysis of a phase IIIb trial with abatacept

Drug-free remission is a desirable goal in rheumatoid arthritis (RA) for both patients and clinicians. The aim of this post hoc analysis was to investigate whether clinical and magnetic resonance imaging (MRI)...

Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan… in Arthritis Research & Therapy (2022)

Article

Impact of tanezumab on health status, non-work activities and work productivity in adults with moderate-to-severe osteoarthritis

To evaluate the impact of tanezumab on health status, non-work activities, and work productivity in a pooled analysis of two large phase 3 osteoarthritis (OA) studies.

Philip G. Conaghan, Lucy Abraham, Lars Viktrup, Paul Cislo in BMC Musculoskeletal Disorders (2022)

Article

Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis

Combining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple as...

Thomas J. Schnitzer, Francis Berenbaum, Philip G. Conaghan… in Rheumatology and Therapy (2021)

Article

Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial

Established thresholds for patient-reported outcomes (PROs) provide clinically relevant responder data from trials. Lorecivivint (LOR) is an intra-articular (IA) therapy in development for knee osteoarthritis ...

Jeyanesh R. S. Tambiah, Sarah Kennedy… in Rheumatology and Therapy (2021)

Article

Investigating the patient acceptable symptom state cut-offs: longitudinal data from a community cohort using the shoulder pain and disability index

This prospective study aimed to determine the patient acceptable symptom state (PASS) cut-off for the patient reported outcome measure shoulder pain and disability index (SPADI), and evaluate predictors of PAS...

Gui Tran, Bright Dube, Sarah R. Kingsbury, Alan Tennant… in Rheumatology International (2020)

Article

Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis

The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis ...

Philip G. Conaghan, Mikkel Østergaard, Orrin Troum… in Arthritis Research & Therapy (2019)

Article

Determining MRI Inflammation Targets When Considering a Rheumatoid Arthritis Treat-to-Target Strategy: Results of a Randomized, Placebo-Controlled Trial

Magnetic resonance imaging (MRI) is increasingly used in patients with rheumatoid arthritis (RA) to determine residual inflammation after treatment and as a predictor of structural damage progression. Establis...

Harris A. Ahmad, Joshua F. Baker, Mikkel Østergaard, June Ye… in Advances in Therapy (2019)

Article

Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis

Osteoarthritis (OA) is common and its prevalence is increased in military service members. In a phase 3 randomized controlled trial (NCT02357459), a single intra-articular injection of an extended-release form...

Michael J. Langworthy, Philip G. Conaghan, Joseph J. Ruane… in Advances in Therapy (2019)

Article

A systematic review assessing non-pharmacological conservative treatment studies for people with non-inflammatory multi-joint pain: clinical outcomes and research design considerations

To systematically review the evidence to determine the clinical outcomes and the important methodological quality features of interventional studies on adults with non-inflammatory multi-joint pain (MJP). Syst...

C. Comer, T. O. Smith, B. Drew, R. Raja, S. R. Kingsbury… in Rheumatology International (2018)

Article

The effect of targeted treatment on people with patellofemoral pain: a pragmatic, randomised controlled feasibility study

Targeted treatment, matched according to specific clinical criteria e.g. hip muscle weakness, may result in better outcomes for people with patellofemoral pain (PFP). However, to ensure the success of future t...

Benjamin T. Drew, Philip G. Conaghan, Toby O. Smith… in BMC Musculoskeletal Disorders (2017)