24 Result(s)

Article

Correction: Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

The objective of this analysis is to evaluate the improvement in spinal pain with ixekizumab, placebo, and adalimumab based on objective measures of inflammation response in patients with ankylosing spondyliti...

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials

The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive versus -negative patients with rheumatoid arthritis (RA). Four early RA abatacept trials ...

Kaleb Michaud, Philip G. Conaghan, Sang Hee Park… in Rheumatology and Therapy (2023)

Article

Real-world evidence: new opportunities for osteoporosis research. Recommendations from a Working Group from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

This narrative review summarises the recommendations of a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) for the co...

Rebecca J. Moon, Jean-Yves Reginster, Nasser M. Al-Daghri… in Osteoporosis International (2023)

Article

Association between outpatient follow-up and incidence of revision after knee and hip replacements: a population-based cohort study

Follow-up visits 5 or 7 years after surgery were recommended for people having primary hip or knee replacement. The benefits of this practice to patients and the healthcare system, however, have not yet been s...

Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn… in BMC Musculoskeletal Disorders (2023)

Article

Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study

MRI bone surface area and femoral bone shape (B-score) measures have been employed as quantitative endpoints in DMOAD clinical trials. Computerized Tomography (CT) imaging is more commonly used for 3D visualiz...

Alan Brett, Michael A. Bowes, Philip G. Conaghan in BMC Musculoskeletal Disorders (2023)

Article

Prediction of flare following remission and treatment withdrawal in early rheumatoid arthritis: post hoc analysis of a phase IIIb trial with abatacept

Drug-free remission is a desirable goal in rheumatoid arthritis (RA) for both patients and clinicians. The aim of this post hoc analysis was to investigate whether clinical and magnetic resonance imaging (MRI)...

Harris A. Ahmad, Joshua F. Baker, Philip G. Conaghan… in Arthritis Research & Therapy (2022)

Article

Impact of tanezumab on health status, non-work activities and work productivity in adults with moderate-to-severe osteoarthritis

To evaluate the impact of tanezumab on health status, non-work activities, and work productivity in a pooled analysis of two large phase 3 osteoarthritis (OA) studies.

Philip G. Conaghan, Lucy Abraham, Lars Viktrup, Paul Cislo in BMC Musculoskeletal Disorders (2022)

Article

Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis

Combining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple as...

Thomas J. Schnitzer, Francis Berenbaum, Philip G. Conaghan… in Rheumatology and Therapy (2021)

Article

Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial

Established thresholds for patient-reported outcomes (PROs) provide clinically relevant responder data from trials. Lorecivivint (LOR) is an intra-articular (IA) therapy in development for knee osteoarthritis ...

Jeyanesh R. S. Tambiah, Sarah Kennedy… in Rheumatology and Therapy (2021)

Article

Very early MRI responses to therapy as a predictor of later radiographic progression in early rheumatoid arthritis

The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis ...

Philip G. Conaghan, Mikkel Østergaard, Orrin Troum… in Arthritis Research & Therapy (2019)

Article

The effect of targeted treatment on people with patellofemoral pain: a pragmatic, randomised controlled feasibility study

Targeted treatment, matched according to specific clinical criteria e.g. hip muscle weakness, may result in better outcomes for people with patellofemoral pain (PFP). However, to ensure the success of future t...

Benjamin T. Drew, Philip G. Conaghan, Toby O. Smith… in BMC Musculoskeletal Disorders (2017)

Article

Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data from 3000 community referrals for shoulder pain

Ultrasound is increasingly used to evaluate shoulder pain, but the benefits of this are unclear. In this study, we examined whether ultrasound-defined pathologies have implications for clinical outcomes.

Gui Tran, Elizabeth M. A. Hensor, Aaron Ray… in Arthritis Research & Therapy (2017)

Article

Synovitis in osteoarthritis: current understanding with therapeutic implications

Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recogniz...

Alexander Mathiessen, Philip G. Conaghan in Arthritis Research & Therapy (2017)

Article

The clinical characteristics of older people with chronic multiple-site joint pains and their utilisation of therapeutic interventions: data from a prospective cohort study

Chronic multiple-site joint pain (MSJP) is common in older people and associated with poor outcomes, yet under-researched. Our aim was to detail the clinical characteristics of people with MSJP and their utili...

Rafi Raja, Bright Dube, Elizabeth M. A. Hensor… in BMC Musculoskeletal Disorders (2016)

Article

A systematic review of the relationship between subchondral bone features, pain and structural pathology in peripheral joint osteoarthritis

Bone is an integral part of the osteoarthritis (OA) process. We conducted a systematic literature review in order to understand the relationship between non-conventional radiographic imaging of subchondral bon...

Andrew J. Barr, T. Mark Campbell, Devan Hopkinson… in Arthritis Research & Therapy (2015)

Article

Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis

Interleukin-7 (IL-7) is a cytokine essential for T-cell lymphopoiesis, survival and polarization with an emerging role in autoimmunity. We previously demonstrated reduced levels of circulating IL-7 in rheumato...

Sarah M Churchman, Jehan J El-Jawhari, Agata N Burska… in Arthritis Research & Therapy (2014)

Article

How do people with knee osteoarthritis use osteoarthritis pain medications and does this change over time? Data from the Osteoarthritis Initiative

The aim of this analysis was to describe comprehensively the cross-sectional and longitudinal patterns of analgesic and nutraceutical medication use for knee osteoarthritis (OA) in a contemporary US cohort and...

Sarah R Kingsbury, Elizabeth MA Hensor, Ceara AE Walsh… in Arthritis Research & Therapy (2013)

Article

The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis

Psoriatic Arthritis (PsA) is estimated to occur in 10-15% of people with psoriasis and accounts for 13% of people attending early arthritis clinics. With an increasing awareness of the poor outcomes associated...

Laura C Coates, Nuria Navarro-Coy, Sarah R Brown… in BMC Musculoskeletal Disorders (2013)

Article

Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis

Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic OA...

Amanda E Nelson, Robert F DeVellis, Jordan B Renner… in Arthritis Research & Therapy (2011)