16 Result(s)

Article

Correction: Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Exploring the Effects of Ixekizumab on Pain in Patients with Ankylosing Spondylitis Based on Objective Measures of Inflammation: Post Hoc Analysis from a Large Randomized Clinical Trial

The objective of this analysis is to evaluate the improvement in spinal pain with ixekizumab, placebo, and adalimumab based on objective measures of inflammation response in patients with ankylosing spondyliti...

Kurt de Vlam, Walter P. Maksymowych, Gaia Gallo, Proton Rahman… in Rheumatology and Therapy (2024)

Article

Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials

The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive versus -negative patients with rheumatoid arthritis (RA). Four early RA abatacept trials ...

Kaleb Michaud, Philip G. Conaghan, Sang Hee Park… in Rheumatology and Therapy (2023)

Article

Association between outpatient follow-up and incidence of revision after knee and hip replacements: a population-based cohort study

Follow-up visits 5 or 7 years after surgery were recommended for people having primary hip or knee replacement. The benefits of this practice to patients and the healthcare system, however, have not yet been s...

Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn… in BMC Musculoskeletal Disorders (2023)

Article

Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study

MRI bone surface area and femoral bone shape (B-score) measures have been employed as quantitative endpoints in DMOAD clinical trials. Computerized Tomography (CT) imaging is more commonly used for 3D visualiz...

Alan Brett, Michael A. Bowes, Philip G. Conaghan in BMC Musculoskeletal Disorders (2023)

Article

Impact of tanezumab on health status, non-work activities and work productivity in adults with moderate-to-severe osteoarthritis

To evaluate the impact of tanezumab on health status, non-work activities, and work productivity in a pooled analysis of two large phase 3 osteoarthritis (OA) studies.

Philip G. Conaghan, Lucy Abraham, Lars Viktrup, Paul Cislo in BMC Musculoskeletal Disorders (2022)

Article

Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis

Combining measures of key core domains (especially pain and function) into a composite endpoint that requires each patient to meet a threshold of improvement for each domain provides information on multiple as...

Thomas J. Schnitzer, Francis Berenbaum, Philip G. Conaghan… in Rheumatology and Therapy (2021)

Article

Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial

Established thresholds for patient-reported outcomes (PROs) provide clinically relevant responder data from trials. Lorecivivint (LOR) is an intra-articular (IA) therapy in development for knee osteoarthritis ...

Jeyanesh R. S. Tambiah, Sarah Kennedy… in Rheumatology and Therapy (2021)

Article

Determining MRI Inflammation Targets When Considering a Rheumatoid Arthritis Treat-to-Target Strategy: Results of a Randomized, Placebo-Controlled Trial

Magnetic resonance imaging (MRI) is increasingly used in patients with rheumatoid arthritis (RA) to determine residual inflammation after treatment and as a predictor of structural damage progression. Establis...

Harris A. Ahmad, Joshua F. Baker, Mikkel Østergaard, June Ye… in Advances in Therapy (2019)

Article

Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis

Osteoarthritis (OA) is common and its prevalence is increased in military service members. In a phase 3 randomized controlled trial (NCT02357459), a single intra-articular injection of an extended-release form...

Michael J. Langworthy, Philip G. Conaghan, Joseph J. Ruane… in Advances in Therapy (2019)

Article

The effect of targeted treatment on people with patellofemoral pain: a pragmatic, randomised controlled feasibility study

Targeted treatment, matched according to specific clinical criteria e.g. hip muscle weakness, may result in better outcomes for people with patellofemoral pain (PFP). However, to ensure the success of future t...

Benjamin T. Drew, Philip G. Conaghan, Toby O. Smith… in BMC Musculoskeletal Disorders (2017)

Article

The clinical characteristics of older people with chronic multiple-site joint pains and their utilisation of therapeutic interventions: data from a prospective cohort study

Chronic multiple-site joint pain (MSJP) is common in older people and associated with poor outcomes, yet under-researched. Our aim was to detail the clinical characteristics of people with MSJP and their utili...

Rafi Raja, Bright Dube, Elizabeth M. A. Hensor… in BMC Musculoskeletal Disorders (2016)

Article

The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis

Psoriatic Arthritis (PsA) is estimated to occur in 10-15% of people with psoriasis and accounts for 13% of people attending early arthritis clinics. With an increasing awareness of the poor outcomes associated...

Laura C Coates, Nuria Navarro-Coy, Sarah R Brown… in BMC Musculoskeletal Disorders (2013)

Article

Assessment and management of neurogenic claudication associated with lumbar spinal stenosis in a UK primary care musculoskeletal service: a survey of current practice among physiotherapists

Neurogenic claudication (NC) is the clinical syndrome commonly associated with lumbar spinal stenosis (LSS). Non-surgical management is recommended as initial treatment, but little is known about current pract...

Christine M Comer, Anthony C Redmond, Howard A Bird… in BMC Musculoskeletal Disorders (2009)

Article

Variability in depression prevalence in early rheumatoid arthritis: a comparison of the CES-D and HAD-D Scales

Depression is common in rheumatoid arthritis (RA), however reported prevalence varies considerably. Two frequently used instruments to identify depression are the Center for Epidemiological Studies Depression ...

Tanya Covic, Julie F Pallant, Alan Tennant, Sally Cox… in BMC Musculoskeletal Disorders (2009)