5 Result(s)
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Article
The scaffold protein Ste5 directly controls a switch-like mating decision in yeast
Before mating, a Saccharomyces cerevisiae yeast cell must detect a partner cell in the vicinity that is expressing large amounts of a sex pheromone. The pheromone detection system involves the MAP kinase signal t...
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Article
Open AccessInferring time derivatives including cell growth rates using Gaussian processes
Often the time derivative of a measured variable is of as much interest as the variable itself. For a growing population of biological cells, for example, the population’s growth rate is typically more importa...
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Article
Open AccessGeneral calibration of microbial growth in microplate readers
Optical density (OD) measurements of microbial growth are one of the most common techniques used in microbiology, with applications ranging from studies of antibiotic efficacy to investigations of growth under...
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Article
Open AccessPredicting metabolic adaptation from networks of mutational paths
Competition for substrates is a ubiquitous selection pressure faced by microbes, yet intracellular trade-offs can prevent cells from metabolizing every type of available substrate. Adaptive evolution is constr...
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Article
Open AccessEstimating numbers of intracellular molecules through analysing fluctuations in photobleaching
The impact of fluorescence microscopy has been limited by the difficulties of expressing measurements of fluorescent proteins in numbers of molecules. Absolute numbers enable the integration of results from di...
