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    Article

    Turning down tau phosphorylation

    Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppre...

    Peter M Fischer in Nature Chemical Biology (2008)

  2. No Access

    Article

    Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

    Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for develop...

    Campbell McInnes, Aveek Mazumdar, Mokdad Mezna… in Nature Chemical Biology (2006)