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  1. No Access

    Article

    Fundamentals of Pharmacokinetics to Assess the Correlation Between Plasma Drug Concentrations and Different Blood Sampling Methods

    Various blood collection methods were developed and used in the pharmacokinetic evaluation of drugs. However, the influence of different blood sampling methods on plasma drug concentrations has not been clarif...

    Wei-Ching Chen, Pei-Wei Huang, Wan-Ling Yang, Yen-Lun Chen… in Pharmaceutical Research (2019)

  2. No Access

    Article

    Commonly Used Excipients Modulate UDP-Glucuronosyltransferase 2B7 Activity to Improve Nalbuphine Oral Bioavailability in Humans

    Nalbuphine (NAL) is a potent opioid analgesic, but can only be administered by injection. The major aim of this study was to develop an oral NAL formulation employing known excipients as UDP-glucuronosyltransf...

    Hong-Jaan Wang, Cheng-Huei Hsiong, Shung-Tai Ho, Min-Jen Lin… in Pharmaceutical Research (2014)

  3. No Access

    Article

    Simultaneous Determination of Buprenorphine, Norbuprenorphine and Naloxone in Human Plasma by LC-MS-MS

    A novel sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method simultaneously determined buprenorphine (BUP) and its active metabolite, norbuprenorphine (NBUP), and a coformul...

    Ting-Yi Chiang, Li-Heng Pao, Cheng-Huei Hsiong, Pei-Wei Huang… in Chromatographia (2011)