5 Result(s)
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Article
Open AccessSolid-phase capture and profiling of open chromatin by spatial ATAC
Current methods for epigenomic profiling are limited in their ability to obtain genome-wide information with spatial resolution. We introduce spatial ATAC, a method that integrates transposase-accessible chrom...
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Article
Open AccessThree-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium
The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid ar...
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Article
High-definition spatial transcriptomics for in situ tissue profiling
Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures...
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Article
Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections
Spatial resolution of gene expression enables gene expression events to be pinpointed to a specific location in biological tissue. Spatially resolved gene expression in tissue sections is traditionally analyze...
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Article
Spatially resolved transcriptome profiling in model plant species
Understanding complex biological systems requires functional characterization of specialized tissue domains. However, existing strategies for generating and analysing high-throughput spatial expression profile...
