Skip to main content

3 Result(s)

within Patrick Aouad Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

and

  1. Article

    Open Access

    Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

    More than 70% of human breast cancers (BCs) are estrogen receptor α-positive (ER+). A clinical challenge of ER+ BC is that they can recur decades after initial treatments. Mechanisms governing latent disease rema...

    Patrick Aouad, Yueyun Zhang, Fabio De Martino, Céline Stibolt… in Nature Communications (2022)

    Download PDF (7296 KB) View Article

  2. Article

    Open Access

    The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

    Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix,...

    Dalya Ataca, Patrick Aouad, Céline Constantin, Csaba Laszlo… in Nature Communications (2020)

    Download PDF (5952 KB) View Article

  3. Article

    Open Access

    Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

    Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset o...

    Stéphanie Cagnet, Dalya Ataca, George Sflomos, Patrick Aouad… in Nature Communications (2018)

    Download PDF (7849 KB) View Article