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  1. Article

    Open Access

    Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3

    KMT2C and KMT2D, encoding histone H3 lysine 4 methyltransferases, are among the most commonly mutated genes in triple-negative breast cancer (TNBC). However, how these mutations may shape epigenomic and transcrip...

    Marco Seehawer, Zheqi Li, Jun Nishida, Pierre Foidart… in Nature Cell Biology (2024)

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    Article

    KDM6A epigenetically regulates subtype plasticity in small cell lung cancer

    Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1, NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually exclusive, but recent evidence shows intra...

    Leslie Duplaquet, Yixiang Li, Matthew A. Booker, Yingtian **e… in Nature Cell Biology (2023)

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    Article

    FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

    How cancer cells adapt to evade the therapeutic effects of drugs targeting oncogenic drivers is poorly understood. Here we report an epigenetic mechanism leading to the adaptive resistance of triple-negative b...

    Yihao Li, **ntao Qiu, **aoqing Wang, Hui Liu, Renee C. Geck… in Nature Cell Biology (2021)

  4. No Access

    Article

    CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity

    Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert other effects, influencing can...

    April C. Watt, Paloma Cejas, Molly J. DeCristo, Otto Metzger-Filho… in Nature Cancer (2021)

  5. No Access

    Article

    FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues

    Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in formalin-fixed, paraffin-embedded (FFPE) tissues. We previous...

    Alba Font-Tello, Nikolas Kesten, Yingtian **e, Len Taing… in Nature Protocols (2020)