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  1. No Access

    Article

    Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects

    Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. It is unclear whether any of these genes, other than dopamine receptor D2, are immediately relevant to a...

    Y Kim, P Giusti-Rodriguez, J J Crowley, J Bryois, R J Nonneman… in Molecular Psychiatry (2018)

  2. Article

    Erratum: Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia

    P H Lee, J T Baker, A J Holmes, N Jahanshad, T Ge, J -Y Jung… in Molecular Psychiatry (2017)

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  3. Article

    Open Access

    Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder

    We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prio...

    A W Charney, D M Ruderfer, E A Stahl, J L Moran, K Chambert… in Translational Psychiatry (2017)

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  4. No Access

    Article

    Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia

    Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic etiology. Widespread cortical gray matter loss has been observed in patients and prodromal samples. However, it remains unresol...

    P H Lee, J T Baker, A J Holmes, N Jahanshad, T Ge, J-Y Jung, Y Cruz… in Molecular Psychiatry (2016)

  5. Article

    Open Access

    Association between polygenic risk for schizophrenia, neurocognition and social cognition across development

    Breakthroughs in genomics have begun to unravel the genetic architecture of schizophrenia risk, providing methods for quantifying schizophrenia polygenic risk based on common genetic variants. Our objective in...

    L Germine, E B Robinson, J W Smoller, M E Calkins, T M Moore… in Translational Psychiatry (2016)

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  6. Article

    Open Access

    Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder

    Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) ...

    P H Lee, R H Perlis, J-Y Jung, E M Byrne, E Rueckert… in Translational Psychiatry (2012)

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  7. No Access

    Article

    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder

    Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders with overlap** susceptibility loci and symptomatology. We conducted a genome-wide association study (GWAS) of these di...

    S E Bergen, C T O'Dushlaine, S Ripke, P H Lee, D M Ruderfer… in Molecular Psychiatry (2012)

  8. No Access

    Article

    A genome-wide association study of attempted suicide

    The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. Although attempted suicide linkage regions have been identified on 2p1...

    V L Willour, F Seifuddin, P B Mahon, D Jancic, M Pirooznia… in Molecular Psychiatry (2012)

  9. Article

    Open Access

    The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data

    The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as pre...

    C M Middeldorp, M H M de Moor, L M McGrath, S D Gordon… in Translational Psychiatry (2011)

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