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  1. No Access

    Chapter and Conference Paper

    Neutralization and Receptor Recognition of Human T-Lymphotropic Retroviruses

    Like other enveloped viruses, the outer membrane antigens of retroviruses present target antigens for neutralizing antibodies, and also play a key role in interacting with cell-surface receptors for initial st...

    R. A. Weiss, P. R. Clapham, A. G. Dalgleish… in Modern Trends in Human Leukemia VII (1987)

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    Chapter and Conference Paper

    The Role of CD4 Antigen in HIV Infection

    Ever since the initial description of acquired immune deficiency syndrome (AIDS), it has been known that a specific depletion of CD4+ T-lymphocytes in the peripheral blood accompanies the onset of immunodeficienc...

    R. A. Weiss, P. R. Clapham, J. A. McKeating in Progress in Immunology (1989)

  3. No Access

    Chapter

    Role of CD4 in the Penetration of Cells by HIV

    Enveloped viruses penetrate host cells by two distinct. mechanisms: by direct fusion between viral and cell membrane or by receptor-mediated endocytosis. Though not mutually exclusive, it is likely that viruse...

    J. S. McDougal, P. J. Maddon, G. Orloff… in Mechanisms and Specificity of HIV Entry in… (1991)

  4. No Access

    Article

    Lack of alternative coreceptor use by pediatric HIV-1 R5 isolates for infection of primary cord or adult peripheral blood mononuclear cells

    HIV-1 infection of neonates results in an extended acute period of virus replication, frequent neurological problems and reduced survival compared to adults. In adults, R5 viruses mainly infect CCR5+ CD4+ memory ...

    W. M. Sullivan, P. Dorr, M. Perros, R. Hudson, J. Leif… in Archives of Virology (2008)