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  1. No Access

    Article

    Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype

    The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen receptor (CAR)-expressing T cells can also undergo mem...

    P Neeson, A Shin, K M Tainton, P Guru, H M Prince, S J Harrison, S Peinert… in Gene Therapy (2010)

  2. No Access

    Article

    Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

    We have evaluated the carbohydrate antigen LewisY (LeY) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary bone marrow samples revealed moderate LeY expression on p...

    S Peinert, H M Prince, P M Guru, M H Kershaw, M J Smyth, J A Trapani… in Gene Therapy (2010)

  3. No Access

    Article

    Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

    There is considerable concern regarding the transforming potential of retroviral vectors currently used for gene therapy, with evidence that retroviral integration can lead to leukemia in recipients of gene-mo...

    J A Westwood, W K Murray, M Trivett, A Shin, P Neeson, D P MacGregor… in Gene Therapy (2008)