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Article
Open AccessThe Emergence of Complexity from a Simple Model for Tissue Growth
The growth of living tissue is known to be modulated by mechanical as well as biochemical signals. We study a simple numerical model where the tissue growth rate depends on a chemical potential describing bioc...
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Article
Open AccessNetwork architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons
A popular hypothesis explains the mechanosensitivity of bone due to osteocytes sensing the load-induced flow of interstitial fluid squeezed through the lacunocanalicular network (LCN). However, the way in whic...
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Article
Open AccessOsteoclasts on Bone and Dentin In Vitro: Mechanism of Trail Formation and Comparison of Resorption Behavior
The main function of osteoclasts in vivo is the resorption of bone matrix, leaving behind typical resorption traces consisting of pits and trails. The mechanism of pit formation is well described, but less is ...
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Article
Open AccessCombination of Nanoindentation and Quantitative Backscattered Electron Imaging Revealed Altered Bone Material Properties Associated with Femoral Neck Fragility
Osteoporotic fragility fractures were hypothesized to be related to changes in bone material properties and not solely to reduction in bone mass. We studied cortical bone from the superior and inferior sectors...
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Article
Open AccessNew Suggestions for the Mechanical Control of Bone Remodeling
Bone is constantly renewed over our lifetime through the process of bone (re)modeling. This process is important for bone to allow it to adapt to its mechanical environment and to repair damage from everyday l...
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Article
Open AccessSpiral twisting of fiber orientation inside bone lamellae
The secondary osteon — a fundamental building block in compact bone — is a multilayered cylindrical structure of mineralized collagen fibrils arranged around a blood vessel. Functionally, the osteon must be ad...
