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  1. No Access

    Article

    Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype

    The anti-tumor efficacy of adoptively transferred T cells requires their in vivo persistence and memory polarization. It is unknown if human chimeric antigen receptor (CAR)-expressing T cells can also undergo mem...

    P Neeson, A Shin, K M Tainton, P Guru, H M Prince, S J Harrison, S Peinert… in Gene Therapy (2010)

  2. No Access

    Article

    Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

    We have evaluated the carbohydrate antigen LewisY (LeY) as a potential target for T-cell immunotherapy of hematological neoplasias. Analysis of 81 primary bone marrow samples revealed moderate LeY expression on p...

    S Peinert, H M Prince, P M Guru, M H Kershaw, M J Smyth, J A Trapani… in Gene Therapy (2010)

  3. No Access

    Article

    Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients

    Myelodysplastic syndrome (MDS) comprises a group of clonal bone marrow disorders characterized by ineffective hematopoiesis and increased predisposition to acute myeloid leukemia. The causes of MDS remain poor...

    A C Chan, P Neeson, E Leeansyah, K Tainton, H Quach, H M Prince, D I Godfrey… in Leukemia (2010)

  4. No Access

    Article

    Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma

    Immunomodulatory drugs (IMiDs) are thalidomide analogues, which possess pleiotropic anti-myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and anti-proliferative effects. Their...

    H Quach, D Ritchie, A K Stewart, P Neeson, S Harrison, M J Smyth, H M Prince in Leukemia (2010)

  5. No Access

    Article

    Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

    There is considerable concern regarding the transforming potential of retroviral vectors currently used for gene therapy, with evidence that retroviral integration can lead to leukemia in recipients of gene-mo...

    J A Westwood, W K Murray, M Trivett, A Shin, P Neeson, D P MacGregor… in Gene Therapy (2008)

  6. No Access

    Article

    Clinical associations and characterisation of antineutrophil cytoplasmic antibodies directed against bactericidal/permeability-increasing protein and azurocidin

    Bactericidal/permeability-increasing protein (BPI) and azurocidin (AZ) are recently described target antigens of antineutrophil cytoplasmic antibodies (ANCA). In this study, BPI-ANCA were demonstrated most of...

    T. Cooper, J. Savige, L. Nassis, B. Paspaliaris, P. Neeson… in Rheumatology International (2000)