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    Article

    A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial

    We recently conducted a pilot study supporting the feasibility, safety, and validity of a human laboratory model of ad libitum cocaine administration in which subjects self-selected the timing of infusions. Th...

    W. J. Lynch, A. Sughondhabirom, B. Pittman, R. Gueorguieva… in Psychopharmacology (2006)

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    Chapter

    The Evolution of Drug-Receptor Models: The Cubic Ternary Complex Model for G Protein-Coupled Receptors

    One of the earliest explicit mathematical representations of drug-receptor kinetics was given by Clark 1933, Clark 1937. It was known as occupancy theory, a name that suggested that occupation of a receptor by a ...

    T. Kenakin, P. Morgan, M. Lutz, J. Weiss in The Pharmacology of Functional, Biochemica… (2000)