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Article
AML patients with CEBPα mutations mostly retain identical mutant patterns but frequently change in allelic distribution at relapse: a comparative analysis on paired diagnosis and relapse samples
The roles of CEBPα mutations and its cooperating mutations in the relapse of acute myeloid leukemia (AML) are not clear. CEBPα mutations were analyzed on 149 patients with de novo AML at both diagnosis and relaps...
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Article
Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement
The fusion transcripts of MLL rearrangement [MLL(+)] in acute myeloid leukemia (AML) and their clinicohematologic correlation have not be well characterized in the previous studies. We used Southern blot analysis...
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Article
All-trans-retinoic acid-induced erythema nodosum in patients with acute promyelocytic leukemia
Erythema nodosum associated with all-trans-retinoic acid (ATRA) for acute promyelocytic leukemia (APL) is very rare. We describe four patients with classic APL who developed erythema nodosum during ATRA therapy. ...
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Article
Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia
The role of internal tandem duplication of fms-like tyrosine kinase 3 (FLT3/ITD), mutations at tyrosine kinase domain (FLT3/TKD) and N-ras mutations in the transformation of myelodysplastic syndrome (MDS) to AML ...