24 Result(s)

Article

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-a...

Anqi Wang, Jiayi Shen, Alex A. Rodriguez, Edward J. Saunders, Fei Chen… in Nature Genetics (2023)

Article

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studie...

David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders… in Nature Genetics (2021)

Article

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Genome-wide association studies (GWAS) and fine-map** efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array...

Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt… in Nature Genetics (2018)

Article

Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Previous genome-wide association studies (GWAS) of prostate cancer risk focused on cases unselected for family history and have reported over 100 significant associations. The International Consortium for Pros...

Craig C. Teerlink, Daniel Leongamornlert, Tokhir Dadaev, Alun Thomas… in Human Genetics (2016)

Article

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

Olivier Delattre and colleagues show that a Ewing sarcoma susceptibility variant at 10q21.3 influences EGR2 expression by altering the activity of an enhancer bound by EWSR1-FLI1. They further show that EGR2 k...

Thomas G P Grünewald, Virginie Bernard, Pascale Gilardi-Hebenstreit… in Nature Genetics (2015)

Article

Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases

Genetic studies have identified single nucleotide polymorphisms (SNPs) associated with the risk of prostate cancer (PC). It remains unclear whether such genetic variants are associated with disease aggressiven...

Brian T. Helfand, Kimberly A. Roehl, Phillip R. Cooper, Barry B. McGuire… in Human Genetics (2015)

Article

Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease

Previous GWAS studies have reported significant associations between various common SNPs and prostate cancer risk using cases unselected for family history. How these variants influence risk in familial prosta...

Craig C. Teerlink, Stephen N. Thibodeau, Shannon K. McDonnell… in Human Genetics (2014)

Article

Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)

Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case–control designs. However, GWAS findings may be confounded by population stratificat...

Guangfu **, Lingyi Lu, Kathleen A. Cooney, Anna M. Ray… in Human Genetics (2012)

Article

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Paul Brennan, Stephen Chanock and colleagues performed a genome-wide association study for renal carcinoma. They identified two genetic susceptibility loci.

Mark P Purdue, Mattias Johansson, Diana Zelenika, Jorge R Toro… in Nature Genetics (2011)

Article

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Montserrat Garcia-Closas and colleagues report a genome-wide association study for bladder cancer. They identify three new susceptibility loci on chromosomes 22q13.1, 19q12 and 2q37.1.

Nathaniel Rothman, Montserrat Garcia-Closas, Nilanjan Chatterjee… in Nature Genetics (2010)

Article

Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager and colleagues with the Cancer Genetics Markers of Susceptibility (CGEMS) initiative report a new association to prostate cancer at chromosome 8q24. This defines a new locus, region 4, which sh...

Meredith Yeager, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs… in Nature Genetics (2009)

Article

Variation in KLK genes, prostate-specific antigen and risk of prostate cancer

Jiyoung Ahn, Sonja I Berndt, Sholom Wacholder, Peter Kraft, Adam S Kibel… in Nature Genetics (2008)

Article

Multiple loci identified in a genome-wide association study of prostate cancer

We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovaria...

Gilles Thomas, Kevin B Jacobs, Meredith Yeager, Peter Kraft… in Nature Genetics (2008)