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Article
Cognitive impact of cytotoxic agents in mice
Adjuvant chemotherapy is associated with changes in cognition in a subgroup of cancer patients. Chemotherapy is generally given as a combination of cytotoxic agents, which makes it hard to define the agent res...
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Article
Open AccessPaclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice
The anticancer drug paclitaxel is formulated for i.v. administration in a mixture of Cremophor EL and ethanol. Its oral bioavailability is very low due to the action of P-glycoprotein in the gut wall and CYP45...
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Article
Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice
Trabectedin is a novel anticancer drug active against soft tissue sarcomas. Trabectedin is a substrate for P-glycoprotein (P-gp), which is encoded by mdr1a/1b in rodents. Plasma and tissue distribution, and excre...
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Article
A population analysis of the pharmacokinetics of Cremophor EL using nonlinear mixed-effect modelling
Abstract
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Article
Pharmacokinetics and metabolism of the staurosporine analogue CGP 41 251 in mice
Studies with CGP 41 251 (I), an N-benzoylstaurosporine derivative and PKC-α inhibitor, revealed that oral administration of 400 μg/day of the compound to wild type mice on four successive days reversed multi d...
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Article
A clinical pharmacokinetics study of carzelesin given by short-term intravenous infusion in a phase I study
We investigated the pharmacokinetic behavior of carzelesin in 31 patients receiving this drug by 10-min intravenous infusion in a Phase I clinical trial, which was conducted at institutions in Nijmegen (insti...
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Article
Oral Bioavailability of Low Dose (20mg) ‘Home-Made’ Etoposide Capsules
The oral bioavailability of etoposide 20mg capsules, which were manufactured in our hospital pharmacy, was studied in 14 patients with various types of solid tumours. The presence of the lubricant colloidal si...
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Article
Unchanged pharmacokinetics of etoposide given by intra-arterial hepatic infusion as compared with i.v. infusion
We investigated the pharmacokinetics of etoposide given to a patient suffering from multifocal liver metastases from an unknown primary tumor. The drug was given either by i.v. infusion or by hepatic arterial...
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Article
Pharmacokinetics of Etoposide after Oral and Intravenous Administration in Patients with Gastric Carcinoma
The effects of the primary tumour in situ or of gastrectomy on the bioavailability and other pharmacokinetic parameters of etoposide, after oral administration of commercially available etoposide (Vepesid®, Brist...
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Article
Antibodies against cisplatin-modified DNA and cisplatin-modified (di) nucleotides
Cytotoxic effects ofcis-diamminedichloroplatinum-(II) (cis-DDP) are thought to be mediated by binding to DNA. Studies on binding ofcis-DDP to cellular DNA rely heavily on the availability of specific antibodies. ...