8 Result(s)

Article

Sphingolipids modulate the epithelial–mesenchymal transition in cancer

T Levade, N Andrieu-Abadie, O Micheau, P Legembre, B Ségui in Cell Death Discovery (2015)

Article

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion

TRAIL is involved in immune tumor surveillance and is considered a promising anti-cancer agent owing to its limited side effects on healthy cells. However, some cancer cells display resistance, or become resis...

A Morlé, C Garrido, O Micheau in Cell Death & Disease (2015)

Article

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells

The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells. The serine/threonine kinase casein kinase 2 (CK2) has a well-reported role in prostate canc...

A de Thonel, A Hazoumé, V Kochin, K Isoniemi, G Jego, E Fourmaux… in Cell Death & Disease (2014)

Article

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIR domain-cont...

Y Estornes, F Toscano, F Virard, G Jacquemin, A Pierrot… in Cell Death & Differentiation (2012)

Article

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level

TNF-related apoptosis-inducing ligand or Apo2L (Apo2L/TRAIL) is a promising anti-cancer drug owing to its ability to trigger apoptosis by binding to TRAIL-R1 or TRAIL-R2, two membrane-bound receptors that are ...

A Morizot, D Mérino, N Lalaoui, G Jacquemin, V Granci… in Cell Death & Differentiation (2011)

Article

Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells

Fas (CD95/Apo-1) ligand is a potent inducer of apoptosis and one of the major killing effector mechanisms of cytotoxic T cells. Thus, Fas ligand activity has to be tightly regulated, involving various transcri...

D Kassahn, U Nachbur, S Conus, O Micheau, P Schneider… in Cell Death & Differentiation (2009)

Article

Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis

Apoptosis is a highly controlled process, whose triggering is associated with the activation of caspases. Apoptosis can be induced via a subgroup of the tumor necrosis factor (TNF) receptor superfamily, which ...

J A Kummer, O Micheau, P Schneider, N Bovenschen… in Cell Death & Differentiation (2007)

Article

E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP_short

E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously postulated that the low level of E2F1 in primary lung adenocarcinoma contributes to ...

C Salon, B Eymin, O Micheau, L Chaperot, J Plumas… in Cell Death & Differentiation (2006)