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Article
Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed i...
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Article
Open AccessInverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age
Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.
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Article
Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study
The aim of this study was to compare novel and established anthropometrical measures in their ability to predict cardiovascular disease (CVD), and to determine whether they improve risk prediction beyond class...
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Article
Open AccessCopeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmö Diet and Cancer Study cardiovascular cohort
High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we...
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Article
Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body mass index (BMI). We...