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  1. No Access

    Article

    DNA microarrays identification of primary and secondary target genes regulated by p53

    The transcriptional program regulated by the tumor suppressor p53 was analysed using oligonucleotide microarrays. A human lung cancer cell line that expresses the temperature sensitive murine p53 was utilized ...

    Karuppiah Kannan, Ninette Amariglio, Gideon Rechavi, Jasmine Jakob-Hirsch… in Oncogene (2001)

  2. No Access

    Article

    DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1

    The transcription regulation activity of p53 controls cellular response to a variety of stress conditions, leading to growth arrest and apoptosis. Despite major progress in the understanding of the global effe...

    Karuppiah Kannan, Naftali Kaminski, Gideon Rechavi, Jasmine Jakob-Hirsch… in Oncogene (2001)

  3. No Access

    Article

    A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

    p53 exerts its tumor suppressor effects by activating genes involved in cell growth arrest and programmed cell death. The p53 target genes inducing growth arrest are well defined whereas those inducing apoptos...

    Galit Rozenfeld-Granot, Janakiraman Krishnamurthy, Karuppiah Kannan, Amos Toren… in Oncogene (2002)

  4. No Access

    Article

    Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer

    To gain insight into the transformation of epidermal cells into squamous carcinoma cells (SCC), we compared the response to ultraviolet B radiation (UVB) of normal human epidermal keratinocytes (NHEK) versus t...

    Jean-Eudes Dazard, Hilah Gal, Ninette Amariglio, Gideon Rechavi, Eytan Domany… in Oncogene (2003)

  5. No Access

    Article

    Sil overexpression in lung cancer characterizes tumors with increased mitotic activity

    Sil (SCL interrupting locus) was cloned from the most common chromosomal rearrangement in T-cell acute lymphoblastic leukemia. It is an immediate early gene whose expression is associated with cell proliferati...

    Ayelet Erez, Marina Perelman, Stephen M Hewitt, Gadi Cojacaru, Iris Goldberg… in Oncogene (2004)

  6. No Access

    Article

    Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer

    On the basis of epidemiological studies, infection was suggested to play a role in the etiology of human cancer. While for some cancers such a role was indeed demonstrated, there is no direct biological suppor...

    Uri Einav, Yuval Tabach, Gad Getz, Assif Yitzhaky, Ugur Ozbek… in Oncogene (2005)