17 Result(s)
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Article
Open AccessInvestigating the relationship between early cardiovascular disease markers and loneliness in young adults
Loneliness is recognised as a risk factor for cardiovascular disease development. However, it is unclear whether loneliness itself or other closely related mental health symptoms, such as depression and social...
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MicroRNA-132 may be associated with blood pressure and liver steatosis—preliminary observations in obese individuals
Recent findings in experimental models have shown that the microRNA miR-132 (mir-132) is an important regulator of liver homeostasis and lipid metabolism. We aimed to assess miR-132 expression in liver and fat...
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Autonomic nervous system function in women with anorexia nervosa
Abnormalities in autonomic function have been observed in people with anorexia nervosa. However, the majority of investigations have utilised heart rate variability as the sole assessment of autonomic activity...
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Open AccessPlasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting
Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypert...
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Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice
BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous system (SNS) and renin–angiotensin system (RAS). BPH/2J display higher renal renin mRNA and low levels of its negati...
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Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes
We determined whether empagliflozin altered renal sympathetic nerve activity (RSNA) and baroreflexes in a diabetes model in conscious rabbits.
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Renal nerves contribute to hypertension in Schlager BPH/2J mice
Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). The kidneys of BPH/2J are hyper-innervated suggesting renal ner...
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Correction to: Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans
The baseline insulin data given in Table 1 for the placebo group were incorrectly reported as 51 ± 10 pmol/l instead of 48 ± 10 pmol/l. This mistake also impacts on data reported in Table 4.
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Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans
Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazoli...
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Open AccessP175: An Acute Bout of Prolonged Sitting Impairs Endothelial Function and Increases Plasma Concentrations of Endothelin-1 In
Compared to regular active breaks, prolonged uninterrupted sitting amplifies postprandial glucose and insulin in overweight/obese adults with and without type 2 diabetes; and impairs lower limb endothelial fun...
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Hypothalamo-pituitary adrenal axis and sympatho-adrenal medullary system responses to psychological stress were not attenuated in women with elevated physical fitness levels
It is not clear if higher levels of cardiorespiratory fitness are associated with lower hypothalamo-pituitary adrenal (HPA) axis and sympatho-adrenal medullary (SAM) system reactivity to psychological stress ...
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Open AccessReduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss
The hyperinsulinemia of obesity is a function of both increased pancreatic insulin secretion and decreased insulin clearance, and contributes to cardiovascular risk. Whilst weight loss is known to enhance insu...
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Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
Brown adipose tissue (BAT) activation increases energy expenditure and may have therapeutic potential to combat obesity. The primary activating and adaptive signal for BAT is via β-adrenergic signalling. We pr...
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Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity
In rabbits, mean arterial pressure (MAP) increases in response to fat feeding, but does not increase further with progressive weight gain. We documented the progression of adiposity and the alterations in endo...
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The Brain and Leptin Resistance and Implications for Food-Related Disorders
Obesity and the chronic diseases associated with obesity are rapidly becoming a public health crisis in the world. The existence of a circulating factor with effects on body weight has long been anticipated. T...
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Mediators of sympathetic activation in metabolic syndrome obesity
The metabolic syndrome represents a major public health burden because of its high prevalence in the general population and its association with cardiovascular disease and type 2 diabetes. Accumulated evidence...
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Neural mechanisms and management of obesity-related hypertension
The sympathetic nervous system is activated in human obesity and in the analogous experimental obesity produced by overfeeding. The causes remain uncertain and may be multiple. The consequences include hyperte...
