34 Result(s)
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Life Sciences
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Article
Aldehyde-amine crosslinked starch-based high-performance wood adhesive
Manufacturing green and sustainable bio-based adhesives is an effective strategy to alleviate both serious energy and environmental issues. Herein, based on the aldehyde–amine covalent reaction between dialdeh...
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Strategies adopted by Salmonella to survive in host: a review
Salmonella, a Gram-negative bacterium that infects humans and animals, causes diseases ranging from gastroenteritis to severe systemic infections. Here, we discuss various strategies used by Salmonella against ho...
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Itaconate inhibits SYK through alkylation and suppresses inflammation against hvKP induced intestinal dysbiosis
Hypervirulent Klebsiella pneumoniae (hvKP) is a highly lethal opportunistic pathogen that elicits more severe inflammatory responses compared to classical Klebsiella pneumoniae (cKP). In this study, we investi...
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Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells
Fluorescent RNAs, aptamers that bind and activate small fluorogenic dyes, have provided a particularly attractive approach to visualizing RNAs in live cells. However, the simultaneous imaging of multiple RNAs ...
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Open AccessAmplicon-based metagenomic association analysis of gut microbiota in relation to egg-laying period and breeds of hens
The gut microbiota plays an essential role in maintaining gut homeostasis and improving performance, with the composition of microbial communities visibly differing across different laying stages in hens and s...
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Plastid phylogenomic insights into relationships, divergence, and evolution of Apiales
Members of Apiales are monophyletic and radiated in the Late Cretaceous. Fruit morphologies are critical for Apiales evolution and negative selection and mutation pressure play important roles ...
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An Adequate Supply of Bis(ethylmaltolato)oxidovanadium(IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer’s Disease in Triple-Transgenic Middle-Aged Mice
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disease with impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis(ethylmaltolato)oxidovanadium(IV) (...
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Open AccessN7-methylguanosine modification of lncRNAs in a rat model of hypoxic pulmonary hypertension: a comprehensive analysis
Long non-coding RNAs (lncRNAs) play a critical role in the pathogenesis of hypoxic pulmonary hypertension (HPH). The role of N7-methylguanosine (m7G) modification in lncRNAs has received increased attentions i...
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Open AccessAuthor Correction: Discovery of new genetic loci for male sexual orientation in Han population
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Open AccessDiscovery of new genetic loci for male sexual orientation in Han population
Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...
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Article
MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma
Neuroblastoma (NB) is one of the most common malignant tumors in children, with variable clinical behaviors and a 15% death rate of all malignancies in childhood. However, genetic susceptibility to sporadic NB...
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Article
Open AccessAKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development
As evidenced by the behavior of loss-of-function mutants of PTEN in the context of a gain-of-function mutation of AKT1, the PTEN-AKT1 signaling pathway plays a critical role in human cancers. In this study, we...
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Open AccessYYFZBJS ameliorates colorectal cancer progression in ApcMin/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation
Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of...
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Open AccessDeletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37
LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com...
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Open AccessExploring the changing landscape of cell-to-cell variation after CTCF knockdown via single cell RNA-seq
CCCTC-Binding Factor (CTCF), also known as 11-zinc finger protein, participates in many cellular processes, including insulator activity, transcriptional regulation and organization of chromatin architecture. ...
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Cell-type-specific and projection-specific brain-wide reconstruction of single neurons
We developed a dual-adeno-associated-virus expression system that enables strong and sparse labeling of individual neurons with cell-type and projection specificity. We demonstrated its utility for whole-brain...
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Article
Omics for understanding the mechanisms of Streptomyces lydicus A01 promoting the growth of tomato seedlings
Tomato is an important vegetable plant worldwide. Previously, we isolated a soilborne Actinobacteria species, Streptomyces lydicus A01, which promotes the growth of tomato seedlings. The related mechanisms are ne...
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Article
BMP7 plays a critical role in TMEM100-inhibited cell proliferation and apoptosis in mouse metanephric mesenchymal cells in vitro
Kidney mainly arises from the induction of metanephric mesenchymal cells (MM cells) and the ureteric bud (UB). Transmembrane protein-100 (Tmem100) consists of two transmembrane regions with strong temporal and...
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Open AccessCombination of berberine and evodiamine inhibits intestinal cholesterol absorption in high fat diet induced hyperlipidemic rats
Hyperlipidemia characterized of elevated serum lipid levels is a prevalent disease frequently resulting in cardiovascular disease (CVD). Berberine and evodiamine are herbal products of traditional Chinese herb Co...
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Effects of stocking density on lipid deposition and expression of lipid-related genes in Amur sturgeon (Acipenser schrenckii)
To investigate the correlation between lipid deposition variation and stocking density in Amur sturgeon (Acipenser schrenckii) and the possible physiological mechanism, fish were conducted in different stocking d...
