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Article
Secretion of polypeptides related to epidermal growth factor and insulinlike growth factor I by a human teratocarcinoma cell line
To identify polypeptide growth factors for human teratocarcinoma cells, we studied the malignant ovarian teratoma-derived cell line, PA-1, that grew autonomously in serum-free medium. Medium conditioned by und...
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Article
Social Exchange in China: The Double-Edged Sword of Guanxi
We present two studies that examine the effects of guanxi on multiple social groups from the perspective of Chinese business people. Study 1 (N = 203) tests the difference in perceived effects of six guanxi conte...
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Article
Visualization of bHLH transcription factor interactions in living mammalian cell nuclei and develo** chicken neural tube by FRET
Members of the basic helix-loop-helix (bHLH) gene family play important roles in vertebrate neurogenesis. In this study, confocal microscopy-based fluorescence resonance energy transfer (FRET) is used to monit...
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Article
ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells
ADAM23, belonging to ADAM (A Disintegrin And Metalloprotease) protein family, is mainly expressed in brain. P19 cells could differentiate into neuroectodermal cell lineage after cell aggregates have been induc...
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Article
rSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cells
Sac domain-containing proteins belong to a newly identified family of phosphoinositide phosphatases (the PIPPase family). Despite well-characterized enzymatic activity, the biological functions of this mammali...
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Article
Id proteins sustain Hes1 expression to maintain neural stem cells
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Article
Transplantation of marrow stromal cells to rescue retinal cells in SI-induced retinal degeneration in rats
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Article
Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 (KDM7A) as a novel histone demethylase specific for the...
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Article
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
The forkhead box transcription factor A2 (FOXA2) is an important regulator in animal development and body homeostasis. However, whether FOXA2 is involved in transforming growth factor β1 (TGF-β1)-mediated epit...
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Article
BMP signaling pathway and spinal cord development
The development of spinal cord is a precisely and sequentially regulated process, which is controlled by signaling pathways and transcription factors in each stage. Overwhelming data have shown the essential r...
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Article
AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning
Bone morphogenetic protein (BMP) inhibits neural specification and induces epidermal differentiation during ectodermal patterning. However, the mechanism of this process is not well understood. Here we show th...
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Chapter
Human Neural Development and Human Embryonic Stem Cell Neural Differentiation
Human neurodevelopment is a key process that is precisely controlled by signaling pathways, intrinsic factors and epigenetic modifications. The previous knowledge of human neurodevelopment has mainly archived ...
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Article
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate
Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well as epigenetic regulators. Nevertheless, how neural fate commitment is ...
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Article
Open AccessThe promise of stem cells in the therapy of Alzheimer’s disease
Alzheimer’s disease (AD), a common neurodegenerative disorder associated with gradually to dramatic neuronal death, synaptic loss and dementia, is considered to be one of the most obscure and intractable brain...
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Article
Open AccessAF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation
AF9 mutations have been implicated in human neurodevelopmental diseases and murine Af9 mediates histone methylation during cortical neuron generation. However, AF9 function and related mechanisms in human neurode...
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Article
Open AccessTRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Generation of β-amyloid (Aβ) peptide in Alzheimer’s disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific...
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Article
Epigenetic regulation of early neural fate commitment
Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by extrinsic signals, intrinsic factors, and epigenet...
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Article
Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome
PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...
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Article
Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq
Geo-seq combines laser capture microdissection and single-cell RNA-seq technology to enable transcriptome analysis of small quantities of cells from defined geographical locations.
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Article
The genome-wide molecular regulation of mouse gastrulation embryo
The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body p...
