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Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction
Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive ...
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Article
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global public health crisis since 2015. ZIKV preferentially infects and targets human neural progenitor cells (hNPCs) and causes ...
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Article
Open AccessRational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection
Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...
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Article
Open AccessPrognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis
Tertiary lymphoid structures (TLSs), organizationally resemble lymph nodes, are frequently present in breast cancer (BCa). It is usually, but not always, associated with a positive prognosis or immunotherapy r...
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Open AccessLong-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates
Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency u...
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Open AccessGm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation
Many integral membrane proteins might act as indispensable coordinators in specific functional microdomains to maintain the normal operation of known receptors, such as Notch. Gm364 is a multi-pass transmembra...
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Open AccessRapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant
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Open AccessLipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of develo** effective antibodies a...
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Open AccessNeutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine