9 Result(s)

Article

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive ...

Zhong Li, Matthew Brecher, Yong-Qiang Deng, **g Zhang, Srilatha Sakamuru… in Cell Research (2017)

Article

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined. Here, we exploited antibody cooperativity to develop a therapeutic an...

Hang** Yao, Yao Sun, Yong-Qiang Deng, Nan Wang, Yongcong Tan… in Cell Research (2021)

Article

Prognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis

Tertiary lymphoid structures (TLSs), organizationally resemble lymph nodes, are frequently present in breast cancer (BCa). It is usually, but not always, associated with a positive prognosis or immunotherapy r...

Na-Na Zhang, Feng-** Qu, Hao Liu, Zhu-Jun Li, Yu-Chi Zhang… in Cancer Cell International (2021)

Article

Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

Messenger RNA (mRNA) vaccine technology has shown its power in preventing the ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency u...

Hui Zhao, Tie-Cheng Wang, **ao-Feng Li… in Signal Transduction and Targeted Therapy (2021)

Article

Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation

Many integral membrane proteins might act as indispensable coordinators in specific functional microdomains to maintain the normal operation of known receptors, such as Notch. Gm364 is a multi-pass transmembra...

Liang-Jian Chen, Na-Na Zhang, Chun-**ang Zhou, Zhi-**a Yang… in Cell Death & Differentiation (2022)

Article

Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant

Na-Na Zhang, Rong-Rong Zhang, Yi-Fei Zhang, Kai Ji, **ao-Chuan **ong… in Cell Research (2022)

Article

Lipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters

Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of develo** effective antibodies a...

Yong-Qiang Deng, Na-Na Zhang, Yi-Fei Zhang, **a Zhong, Sue Xu… in Cell Research (2022)

Article

Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine

Hui Zhao, Na-Na Zhang, Suad Hannawi, Ai-Ru Zhu, **ao-Chuan **ong… in Cell Discovery (2024)