18 Result(s)

Article

Identification of a novel cathelicidin antimicrobial peptide from ducks and determination of its functional activity and antibacterial mechanism

The family of antimicrobial peptide, cathelicidins, which plays important roles against infections in animals, has been identified from many species. Here, we identified a novel avian cathelicidin ortholog fro...

Wei Gao, Liwei **ng, Pei Qu, Tingting Tan, Na Yang, Dan Li… in Scientific Reports (2015)

Article

Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE₂

Chemotherapies often induce drug-resistance in cancer cells and simultaneously stimulate proliferation and activation of Myeloid-Derived Suppressor Cells (MDSCs) to inhibit anti-tumor T cells, thus result in p...

Yuan Rong, Chun-Hui Yuan, Zhen Qu, Hu Zhou, Qing Guan, Na Yang… in Scientific Reports (2016)

Article

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors

A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of ...

Bing Yang, Yu-Shun Yang, Na Yang, Guigen Li, Hai-Liang Zhu in Scientific Reports (2016)

Article

Compound danshen drip** pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia

The continuous administration of compound danshen drip** pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in...

Jiahua Guo, Yonghong Yong, Jiye Aa, Bei Cao, Runbin Sun, **aoyi Yu… in Scientific Reports (2016)

Article

Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules

Bovine lactoferricin (LfcinB) has potent antibacterial, antifungal and antiparasitic activities but is also hemolytic. Our objective was to identify LfcinB17-31 derivatives with reduced hemolysis and improved ...

Ya Hao, Na Yang, **umin Wang, Da Teng, Ruoyu Mao, **ao Wang… in Scientific Reports (2017)

Article

Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis

NZ17074 (N1), an arenicin-3 derivative isolated from the lugworm, has potent antibacterial activity and is cytotoxic. To reduce its cytotoxicity, seven N1 analogues with different structures were designed by c...

Na Yang, Xuehui Liu, Da Teng, Zhanzhan Li, **umin Wang, Ruoyu Mao… in Scientific Reports (2017)

Article

The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells

Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and underlying mechanisms are not clear. Our previous...

Chun Ge, Bei Cao, Dong Feng, Fang Zhou, **gwei Zhang, Na Yang… in Scientific Reports (2017)

Article

Polymorphism in ERCC1 confers susceptibility of coronary artery disease and severity of coronary artery atherosclerosis in a Chinese Han population

Excision repair cross-complementing 1 (ERCC1) gene encodes ERCC1 protein, which is mainly responsible for the repair of DNA damage in different diseases including coronary artery atherosclerosis by acting as a...

Shuai Zhang, Xue-bin Wang, Ya-di Han, Chen-ling **ong, Ye Zhou… in Scientific Reports (2017)

Article

Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermeti...

Zhanzhan Li, Ruoyu Mao, Da Teng, Ya Hao, Huixian Chen, **umin Wang… in Scientific Reports (2017)

Article

Increased intracellular activity of MP1102 and NZ2114 against Staphylococcus aureus in vitro and in vivo

Treatment of Staphylococcus aureus infections remains very difficult due to its capacity to survive intracellularly and its multidrug resistance. In this study, the extracellular/intracellular activities of plect...

**ao Wang, **umin Wang, Da Teng, Ruoyu Mao, Ya Hao, Na Yang… in Scientific Reports (2018)

Article

A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

Long noncoding RNAs (lncRNAs) have emerged as important components of gene regulatory network in embryonic stem cells (ESCs). However, the function and molecular mechanism of lncRNAs are still largely unknown....

Ya-Pu Li, Fei-Fei Duan, Yu-Ting Zhao, Kai-Li Gu, Le-Qi Liao… in Nature Communications (2019)

Article

Oxidative cyclo-rearrangement of helicenes into chiral nanographenes

Nanographenes are emerging as a distinctive class of functional materials for electronic and optical devices. It is of remarkable significance to enrich the precise synthetic chemistry for these molecules. Her...

Chengshuo Shen, Guoli Zhang, Yongle Ding, Na Yang, Fuwei Gan… in Nature Communications (2021)

Article

Triglyceride to HDL-C ratio is associated with plasma D-dimer levels in different types of pancreatitis

This study aims to evaluate levels of D-dimer and serum lipid in different types of pancreatitis, and the relationship between D-dimer and dyslipidemia, especially triglyceride to HDL-C ratio (TG/HDL-C) in dif...

**aoqing Jia, **aoting Zhang, Dalong Sun, Na Yang, Rong Li, Zheng Luo in Scientific Reports (2022)

Article

Author Correction: Triglyceride to HDL-C ratio is associated with plasma D-dimer levels in different types of pancreatitis

**aoqing Jia, **aoting Zhang, Dalong Sun, Na Yang, Rong Li, Zheng Luo in Scientific Reports (2022)

Article

A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations

Therapeutic responses of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) - tyrosine kinase inhibitors (TKIs) are known to be associated with EGFR mutations. However, a proportion of ...

Hui Deng, Qian Lei, Chengdi Wang, Zhoufeng Wang, Hai Chen… in Nature Communications (2022)

Article

Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

We investigated the relationship between dyslipidemia and drug-induced liver injury (DILI), especially the level of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) in severe DILI. In this...

**aoqing Jia, **aoting Zhang, Ming Yan, Dalong Sun, Rong Li, Na Yang… in Scientific Reports (2023)

Article

Shortening/re-lengthening and nailing versus bone transport for the treatment of segmental femoral bone defects

Segmental femoral bone defects are a severe challenge for orthopedic trauma surgeons. The objective of this study was to compare the efficacy of the shortening/re-lengthening and nailing (SRN) technique with t...

Na Yang, Teng Ma, Lu Liu, YiBo Xu, Zhong Li, Kun Zhang, Qian Wang… in Scientific Reports (2023)

Article

High hydrostatic pressure stimulates microbial nitrate reduction in hadal trench sediments under oxic conditions

Hadal trenches are extreme environments situated over 6000 m below sea surface, where enormous hydrostatic pressure affects the biochemical cycling of elements. Recent studies have indicated that hadal trenche...

Na Yang, Yongxin Lv, Mukan Ji, Shiguo Wu, Yu Zhang in Nature Communications (2024)