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  1. Article

    Open Access

    CD19/CD20 dual-targeted chimeric antigen receptor-engineered natural killer cells exhibit improved cytotoxicity against acute lymphoblastic leukemia

    Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy. However, our prior study revealed challenge...

    Na Yang, Caili Zhang, Yingchun Zhang, Yuting Fan… in Journal of Translational Medicine (2024)

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  2. Article

    Open Access

    Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase

    Triple-negative breast cancer (TNBC) is one of the most aggressive human cancers and has poor prognosis. Approximately 80% of TNBC cases belong to the molecular basal-like subtype, which can be exploited thera...

    Jie Lei, Yujia Pan, Rui Gao, Bin He, Zifeng Wang… in Journal of Translational Medicine (2023)

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  3. No Access

    Article

    Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis

    Aberrant activation of cardiac fibroblasts is the main cause and character of cardiac fibrosis, and inhibition of cardiac fibrosis becomes a promising treatment for cardiac diseases. Platelet-activating factor...

    Tian-yu Li, Wei Su, Liang-liang Li, **ao-guang Zhao, Na Yang… in Acta Pharmacologica Sinica (2022)

  4. No Access

    Article

    Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling

    Obesity is an important independent risk factor for cardiovascular diseases, remaining an important health concern worldwide. Evidence shows that saturated fatty acid-induced inflammation in cardiomyocytes con...

    Ke Lin, Na Yang, Wu Luo, **-fu Qian, Wei-wei Zhu, Shi-ju Ye… in Acta Pharmacologica Sinica (2022)

  5. No Access

    Article

    Combination of tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles

    Drugs that induce thrombosis in the tumour vasculature have not resulted in long-term tumour eradication owing to tumour regrowth from tissue in the surviving rim of the tumour, where tumour cells can derive n...

    Su** Li, Yinlong Zhang, Shih-Hsin Ho, Bozhao Li… in Nature Biomedical Engineering (2020)

  6. No Access

    Article

    The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation

    Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically. Our pilot experiments and accumulated evidences showed that epalrestat inh...

    Jun He, Hao-xue Gao, Na Yang, **ao-dong Zhu, Run-bin Sun… in Acta Pharmacologica Sinica (2019)

  7. Article

    In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

    Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-...

    Na Yang, Run-bin Sun, **ng-long Chen, Le Zhen, Chun Ge… in Acta Pharmacologica Sinica (2017)

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