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  1. No Access

    Article

    Immunological Efficacy and Safety of Synthesized CpG Oligodeoxynucleotides

    The technology for synthesis is described, and the adjuvant properties of CpG oligodeoxynucleotides (CpG-ODNs) are assessed. CpG-ODN sequences were generated according to the available sequences on an automati...

    O. M. Kudriavtseva, A. P. Semakova, N. I. Mikshis… in Applied Biochemistry and Microbiology (2018)

  2. Article

    Effect of Antigens Obtained from the Recombinant Strain Bacillus anthracis 55ΔTPA-1Spo– on Organs and Tissues of Immunized Animals

    The recombinant B. anthracis strain 55ΔTPA-1Spo– was used for the development and trial of a method for the simultaneous production of immunogenic anthrax antigens, a protective antigen, and the EA1 protein of th...

    N. I. Mikshis, P. Yu. Popova, A. P. Semakova… in Applied Biochemistry and Microbiology (2018)

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  3. No Access

    Article

    A method for differentiation of Bacillus anthracis strains and phylogenetically related species based on determination of the structural differences between chromosomal genes for biosynthesis of flagellin and methionine

    Nucleotide sequence analysis of several genes responsible for definitive properties of the anthrax pathogen—motility and penicillinase activity—determined a chromosomal locus promising for interspecies differe...

    N. I. Mikshis, T. N. Kashtanova… in Molecular Genetics, Microbiology and Virol… (2015)

  4. No Access

    Article

    Identification of differences in structure of methionine biosynthesis genes in Bacillus anthracis strains and phylogenetically related species of bacilli

    Comparative analysis of nucleotide sequences in genes that encode synthesis of methionine metabolism enzymes in the Bacillus anthracis strains and closely related bacterial species was conducted. A 42-bp deletion...

    N. I. Mikshis, Yu. N. Zhivova… in Molecular Genetics, Microbiology and Virol… (2012)

  5. No Access

    Article

    Asporogenic recombinant producer of anthrax protective antigen

    An asporogenic recombinant strain Bacillus anthracis 55ΔTPA-1(Spo−) producing anthrax protective antigen (PA) was obtained. The strain contains structural gene pag as a part of a hybrid replicon pUB110PA-1 and la...

    N. I. Mikshis, O. M. Kudryavtseva, D. V. Shulepov… in Applied Biochemistry and Microbiology (2011)

  6. No Access

    Article

    Immunogenicity of recombinant Bacillus strains with a cloned gene for synthesis of the protective antigen of Bacillus anthracis

    A hybrid plasmid pUB110PA-1, which functions stably in cells of Bacillus strains and contains the gene for synthesis of the protective antigen of the anthrax microbe, Bacillus anthracis, has been constructed. Rec...

    N. I. Mikshis, O. M. Kudryavtseva… in Molecular Genetics, Microbiology and Virol… (2007)