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Article
Immunological Efficacy and Safety of Synthesized CpG Oligodeoxynucleotides
The technology for synthesis is described, and the adjuvant properties of CpG oligodeoxynucleotides (CpG-ODNs) are assessed. CpG-ODN sequences were generated according to the available sequences on an automati...
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Article
Effect of Antigens Obtained from the Recombinant Strain Bacillus anthracis 55ΔTPA-1Spo– on Organs and Tissues of Immunized Animals
The recombinant B. anthracis strain 55ΔTPA-1Spo– was used for the development and trial of a method for the simultaneous production of immunogenic anthrax antigens, a protective antigen, and the EA1 protein of th...
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Article
Asporogenic recombinant producer of anthrax protective antigen
An asporogenic recombinant strain Bacillus anthracis 55ΔTPA-1(Spo−) producing anthrax protective antigen (PA) was obtained. The strain contains structural gene pag as a part of a hybrid replicon pUB110PA-1 and la...