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    Article

    Pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) in comparison with cisplatin following a single intravenous injection in rabbits

    The pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) (1-OHP, NSC-266046), a second-generation antitumor platinum complex, was studied in rabbits and compared with that of cisplatin. The rabbits w...

    Ryoichi Kizu, Shin-ichi Higashi, Yoshinori Kidani in Cancer Chemotherapy and Pharmacology (1993)

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    Chapter

    Orally Active DACH-Pt (IV) Compounds

    Since the discovery of the antitumor activity of cisplatin by Rosenberg, et al.1 in 1969, many attempts have been made to prepare highly antitumor active Pt complexes without severe toxicities. The authors discov...

    Yoshinori Kidani, Ryoichi Kizu in Platinum and Other Metal Coordination Comp… (1996)