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Article
Pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) in comparison with cisplatin following a single intravenous injection in rabbits
The pharmacokinetics of (1R,2R-diaminocyclohexane)oxalatoplatinum(II) (1-OHP, NSC-266046), a second-generation antitumor platinum complex, was studied in rabbits and compared with that of cisplatin. The rabbits w...
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Chapter
Orally Active DACH-Pt (IV) Compounds
Since the discovery of the antitumor activity of cisplatin by Rosenberg, et al.1 in 1969, many attempts have been made to prepare highly antitumor active Pt complexes without severe toxicities. The authors discov...