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    Article

    A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids

    The physicochemical properties of nucleic acids are dominated by their highly charged phosphodiester backbone chemistry. This polyelectrolyte structure decouples information content (base sequence) from bulk p...

    Sebastian Arangundy-Franklin, Alexander I. Taylor, Benjamin T. Porebski… in Nature Chemistry (2019)

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    Chapter

    On the Use of SCRF Methods in Drug Design Studies

    Self consistent reaction field (SCRF) methods have been largely used to examine solvent effects in chemical interactions. These methods’ are designed to determine solvation free energy, which is the reversible...

    Modesto Orozco, Carles Colominas… in Molecular Modeling and Prediction of Bioac… (2000)