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    Article

    In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies

    The Scatchard plot of anti-insulin antibodies is curvilinear, indicating heterogeneity in binding sites. However, the relationship between bound insulin (B) and free insulin (F) in patients with anti-insulin anti...

    Hiroyuki Asaka, Shigehiro Karashima, Daisuke Chujo in Diabetology International (2023)

  2. Article

    Open Access

    Artificial Intelligence in Current Diabetes Management and Prediction

    Artificial intelligence (AI) can make advanced inferences based on a large amount of data. The mainstream technologies of the AI boom in 2021 are machine learning (ML) and deep learning, which have made signif...

    Akihiro Nomura, Masahiro Noguchi, Mitsuhiro Kometani in Current Diabetes Reports (2021)

  3. Article

    Open Access

    Effect of sodium–glucose cotransporter-2 inhibitors on aldosterone-to-renin ratio in diabetic patients with hypertension: a retrospective observational study

    Plasma aldosterone-to-renin ratio (ARR) is popularly used for screening primary aldosteronism (PA). Some medications, including diuretics, are known to have an effect on ARR and cause false-negative and false-...

    Toshitaka Sawamura, Shigehiro Karashima, Satoshi Nagase in BMC Endocrine Disorders (2020)

  4. Article

    Open Access

    Study Protocol for the Effects of Artificial Intelligence (AI)-Supported Automated Nutritional Intervention on Glycemic Control in Patients with Type 2 Diabetes Mellitus

    Nutritional intervention is effective in improving glycemic control in patients with type 2 diabetes but requires large inputs of manpower. Recent improvements in photo analysis technology facilitated by artif...

    Rie Oka, Akihiro Nomura, Ayaka Yasugi, Mitsuhiro Kometani, Yuko Gondoh in Diabetes Therapy (2019)

  5. Article

    Open Access

    C-Peptide Area Under the Curve at Glucagon Stimulation Test Predicts Glucose Improvements by GLP-1 Receptor Analogue: A Retrospective Observational Study

    Despite the widespread use of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1ras) to improve glycemic regulation, with a low risk of hypoglycemia and weight reduction, their effectiveness varies among...

    Azusa Ohbatake, Kunimasa Yagi, Shigehiro Karashima, Yuki Shima in Diabetes Therapy (2019)