-
Article
Open AccessRegenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Scales are mineralised exoskeletal structures that are part of the dermal skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony fish have retained a mineralised dermal ...
-
Article
Open AccessA metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes
The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and hyperactivation of the TLRs and subsequent inflammatory consequences have been implicated as risk factors for more severe forms...
-
Article
Open AccessGenetic impact of blood C-reactive protein levels on chronic spinal & widespread pain
Causal mechanisms underlying systemic inflammation in spinal & widespread pain remain an intractable experimental challenge. Here we examined whether: (i) associations between blood C-reactive protein (CRP) an...
-
Article
Open AccessNovel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform
Alzheimer’s disease (AD) is a complex genetic disease, and variants identified through genome-wide association studies (GWAS) explain only part of its heritability. Epistasis has been proposed as a major contr...
