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Article
Open AccessGenome-wide analysis of wheat xyloglucan endotransglucosylase/hydrolase (XTH) gene family revealed TaXTH17 involved in abiotic stress responses
Environmental stresses, including high salinity and drought, severely diminish wheat yield and quality globally. The xyloglucan endotransglucosylase/hydrolase (XTH) family represents a class of cell wall-modif...
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Article
Risk prediction for preeclampsia in CKD patients: development of a model in a retrospective cohort
Chronic kidney disease (CKD) may affect women of childbearing age and may lead to substantial maternal and foetal morbidity and mortality in pregnancy. There is a lack of prediction models for preeclampsia a...
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Article
Open AccessOsAlR3 regulates aluminum tolerance through promoting the secretion of organic acids and the expression of antioxidant genes in rice
In acidic soils, aluminum (Al) toxicity inhibits the growth and development of plant roots and affects nutrient and water absorption, leading to reduced yield and quality. Therefore, it is crucial to investiga...
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Article
Open AccessIntein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast
While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede broad applications. Here, we demonstrate the compl...
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Article
Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the USP2-NCOA4 axis
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive system. Hypoxia is a crucial player in tumor ferroptosis resistance. However, the molecular mechanism of hypoxia-mediated fe...
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Article
DAABNet: depth-wise asymmetric attention bottleneck for real-time semantic segmentation
With the increasing demand for the real-world applications such as autonomous driving and video surveillance, lightweight semantic segmentation methods achieving good trade-offs in terms of parameter size, spe...
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Article
Open AccessThe neural origin for asymmetric coding of surface color in the primate visual cortex
The coding privilege of end-spectral hues (red and blue) in the early visual cortex has been reported in primates. However, the origin of such bias remains unclear. Here, we provide a complete picture of the e...
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Article
Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology
Depression has increasingly become a disease that seriously harms people’s mental health around the world. Icariin is the main active component of Epimedii Herba and effective on protecting the central nervous sy...
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Article
Genetic, clinical, and pathological study of patients with severe hypertension-associated renal microangiopathy
Severe hypertension may be a prominent manifestation of complement-mediated thrombotic microangiopathy. Furthermore, patients with severe hypertension-associated thrombotic microangiopathy may present with con...
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Article
Open AccessGenetic diversity of Aedes aegypti and Aedes albopictus from cohabiting fields in Hainan Island and the Leizhou Peninsula, China
Aedes aegypti and Ae. albopictus are important human arbovirus vectors that can spread arboviral diseases such as yellow fever, dengue, chikungunya and Zika. These two mosquito species coexist on Hainan Island an...
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Article
Open AccessDown-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer
N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal...
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Article
The role of pyroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell death is an effective strat...
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Article
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial
There is a paucity of high-quality evidence on the effectiveness and safety of salt reduction strategies, particularly for older people, who have the most to benefit but are at higher risk of adverse effects. ...
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Article
Open AccessBrain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
The brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link betwe...
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Article
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: an entity associated with distinct diseases and comparison between IgG1 and IgG3 subtypes
The aim of the study was to investigate the clinicopathological characteristics and prognosis of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) and determine the differences ...
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Article
Fault-controlled regional magmatism and mineral deposition in central Cathaysia—Evidence from ambient noise tomography
Guangdong Province in the central Cathaysian Block has two world-class metallogenic belts, namely, the Nanling and Southeastern Coastal Metallogenic Belts (NLMB and SCMB), which are spatially coincide with the...
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Article
Correction to: Low-dose aspirin for the prevention of severe preeclampsia in patients with chronic kidney disease: a retrospective study
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Article
Low-dose aspirin for the prevention of severe preeclampsia in patients with chronic kidney disease: a retrospective study
The objective of the study was to investigate the effects of low-dose aspirin (LDA) during pregnancy on the prevention of preeclampsia in patients with chronic kidney disease (CKD).
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Article
Open AccessTranscriptome profile of goat folliculogenesis reveals the interaction of oocyte and granulosa cell in correlation with different fertility population
To understand the molecular and genetic mechanisms related to the litter size in one species of two different populations (high litter size and low litter size), we performed RNA-seq for the oocytes and granul...
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Article
Open AccessThe pathological features of leukemic cells infiltrating the renal interstitium in chronic lymphocytic leukemia/small lymphocytic lymphoma from a large single Chinese center
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare in Asians, and patients with CLL/SLL seldomly undergo kidney biopsy. The histopathological features and clinical relevance of tubuloint...
