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  1. No Access

    Article

    The function of multiple IκB : NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis

    The Rel/NF-κB transcription factors play a key role in the regulation of apoptosis and in tumorigenesis by controlling the expressions of specific genes. To determine the role of the constitutive activity of R...

    Qiang G Dong, Guido M Sclabas, Shuichi Fujioka, Christian Schmidt, Bailu Peng… in Oncogene (2002)

  2. No Access

    Article

    Novel candidate tumor marker genes for lung adenocarcinoma

    Using the representational difference analysis (RDA) technique on pooled mRNA of five primary lung adenocarcinomas and their corresponding non-neoplastic lung tissues, we identified six genes that were putativ...

    Kan-kan Wang, Ni Liu, Nikolina Radulovich, Dennis A Wigle, Michael R Johnston… in Oncogene (2002)

  3. No Access

    Article

    Modeling of lung cancer by an orthotopically growing H460SM variant cell line reveals novel candidate genes for systemic metastasis

    Endobronchial implantation of NCI-H460 cells into the nude rat generates a primary lung tumor with mediastinal lymph node spread, but rarely systemic metastases. We isolated tumor cells from mediastinal nodes,...

    Jiang Liu, Fiona Blackhall, Isolde Seiden-Long, Igor Jurisica, Roya Navab… in Oncogene (2004)

  4. No Access

    Article

    Identification of 27 5′ CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers

    Aberrantly methylated DNA fragments were searched for in human pancreatic cancers, using the genome scanning technique: methylation-sensitive-representational difference analysis (MS-RDA). MS-RDA isolated 111 ...

    Atsushi Hagihara, Kazuaki Miyamoto, Junichi Furuta, Nobuyoshi Hiraoka… in Oncogene (2004)

  5. No Access

    Article

    Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression

    Lung cancer is the most widely diagnosed malignancy in the world. Understanding early-stage disease will give insight into its pathogenesis. Despite the fact that pre-invasive lesions are challenging to isolat...

    Cathie Garnis, Jonathan J Davies, Timon P H Buys, Ming-Sound Tsao… in Oncogene (2005)

  6. No Access

    Article

    KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers

    Gain of chromosome 1q31–1q32 is seen in >50% of retinoblastoma and is common in other tumors. To define the minimal 1q region of gain, we determined genomic copy number by quantitative multiplex PCR of 14 sequ...

    Timothy W Corson, Annie Huang, Ming-Sound Tsao, Brenda L Gallie in Oncogene (2005)

  7. Article

    Open Access

    Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies

    The advent of personalized medicine requires robust, reproducible biomarkers that indicate which treatment will maximize therapeutic benefit while minimizing side effects and costs. Numerous molecular signatur...

    Maud HW Starmans, Melania Pintilie, Thomas John, Sandy D Der… in Genome Medicine (2012)

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  8. Article

    Open Access

    Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

    The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical ...

    Tracy L. Stockley, Amit M. Oza, Hal K. Berman, Natasha B. Leighl… in Genome Medicine (2016)

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  9. No Access

    Article

    Rho guanine nucleotide exchange factor ARHGEF10 is a putative tumor suppressor in pancreatic ductal adenocarcinoma

    Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are ...

    Joella Joseph, Nikolina Radulovich, Tao Wang, Vibha Raghavan, Chang-Qi Zhu… in Oncogene (2020)