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Rho guanine nucleotide exchange factor ARHGEF10 is a putative tumor suppressor in pancreatic ductal adenocarcinoma

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  1. Article

    Open Access

    Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial

    The clinical utility of molecular profiling of tumor tissue to guide treatment of patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency of genomic alterations, clinical ...

    Tracy L. Stockley, Amit M. Oza, Hal K. Berman, Natasha B. Leighl… in Genome Medicine (2016)

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  2. Article

    Open Access

    Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies

    The advent of personalized medicine requires robust, reproducible biomarkers that indicate which treatment will maximize therapeutic benefit while minimizing side effects and costs. Numerous molecular signatur...

    Maud HW Starmans, Melania Pintilie, Thomas John, Sandy D Der… in Genome Medicine (2012)

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