44 Result(s)
within
Ming-Feng **a
Oncology
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Article
Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors
Breast cancer is a heterogeneous and complex etiological disease. Understanding perturbations of circulating metabolites could improve prognosis.
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Article
Open AccessArtificial intelligence-based assessment of PD-L1 expression in diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is an aggressive blood cancer known for its rapid progression and high incidence. The growing use of immunohistochemistry (IHC) has significantly contributed to the detail...
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Article
Develo** Strategies to Improve the Efficacy of CAR-T Therapy for Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a fatal blood malignancy. With the development of immunotherapy, particularly chimeric antigen receptor T cells (CAR-T), the treatment of AML has undergone a significant change....
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Article
MAP3K1 expression is associated with progression and poor prognosis of hormone receptor-positive, HER2-negative early-stage breast cancer
In this study, we assessed whether the overexpression of MAP3K1 promotes the proliferation, migration, and invasion of breast cancer cells, which affect the prognosis of hormone receptor (HR)–positive, human e...
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Article
Open AccessInvolvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts
Reprogramming of metabolism is strongly associated with the development of cancer. However, the role of metabolic reprogramming in the remodeling of pre-metastatic niche (PMN), a key step in metastasis, is sti...
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Open AccessRelevance of the MHC region for breast cancer susceptibility in Asians
Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Imputing HLA genotypes from existing single-nucleotide polymorphism datasets is low-cost and...
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Article
Open AccessAssociation of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan
The trend of women suffering from early-onset breast cancer is increasing in Taiwan. The association of early-onset breast cancer with body mass index (BMI), menarche, and menopausal status has focused interes...
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Article
Open AccessAdjuvant postmastectomy radiotherapy might be associated with better survival in women with heart failure receiving total mastectomy
To date, no data on the effect of adjuvant postmastectomy radiotherapy (PMRT) on oncologic outcomes, such as all-cause death, locoregional recurrence (LRR), and distant metastasis (DM), are available in women ...
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Article
Open AccessInterleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction
Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism and function of IL-37 in colorectal cancer (CRC) has been elusive. Her...
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Article
Assessing the Evolution of Intracranial Hematomas by using Animal Models: A Review of the Progress and the Challenges
Stroke has become the second leading cause of death in people aged higher than 60 years, with cancer being the first. Intracerebral hemorrhage (ICH) is the most lethal type of stroke. Using imaging techniques ...
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Article
Open AccessAnalysis of the pan-Asian subgroup of patients in the NALA Trial: a randomized phase III NALA Trial comparing neratinib+capecitabine (N+C) vs lapatinib+capecitabine (L+C) in patients with HER2+metastatic breast cancer (mBC) previously treated with two or more HER2-directed regimens
Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, has demonstrated systemic efficacy and intracranial activity in various stages of HER2+breast cancer. NALA was a phase III randomized trial that as...
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Article
Open AccessEffects of Good Pain Management (GPM) ward program on patterns of care and pain control in patients with cancer pain in Taiwan
The undertreatment of cancer pain is a global issue although many international guidelines and various studies bloom to explore the approaches in pain management. However, there is no standard care for cancer ...
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Article
Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer
Mitochondrial unfolding protein are abundant in breast cancer cells, but the mechanism by which breast cancer cells resist apoptosis is still not fully elucidated. In this study, we explored the role of mitoch...
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Open AccessEffect of eribulin on patients with metastatic breast cancer: multicenter retrospective observational study in Taiwan
The aim of this study was to confirm the therapeutic role of eribulin on Taiwanese women with metastatic breast cancer.
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Article
Open AccessWild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7–CYFIP1-mediated signaling pathway
The early onset breast cancer patients (age ≤ 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecul...
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Article
Chinese guidelines for treatment of adult primary immune thrombocytopenia
Primary immune thrombocytopenia (ITP) is a bleeding disorder commonly encountered in clinical practice. The International Working Group (IWG) on ITP has published several landmark papers on terminology, defini...
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Article
Open AccessAltered monocyte differentiation and macrophage polarization patterns in patients with breast cancer
Macrophage heterogeneity is the main feature of the tumour microenvironment. Breast cancer is one of the most life-threatening cancers. However, macrophage polarization patterns in different tumour stages and ...
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Article
Open AccessStearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN
Diabetic patients have a higher risk factor for colorectal cancer (CRC) metastasis. Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fat...
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Article
Open AccessLGR5 overexpression confers poor relapse-free survival in breast cancer patients
Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/β-catenin pathway. Leucine-rich repeat-containing G protein-cou...
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Article
Reactive oxygen species mediated T lymphocyte abnormalities in an iron-overloaded mouse model and iron-overloaded patients with myelodysplastic syndromes
The adverse effects of iron overload have raised more concerns as a growing number of studies reported its association with immune disorders. This study aimed to investigate alterations in the immune system by...
