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1,466 Result(s)
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Article
Open AccessGenetic diversity and prevalence of emerging Rickettsiales in Yunnan Province: a large-scale study
Rickettsia and related diseases have been identified as significant global public health threats. This study involved comprehensive field and systematic investigations of various rickettsial organisms in Yunna...
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Open AccessModelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition
Eukaryotic cell rheology has important consequences for vital processes such as adhesion, migration, and differentiation. Experiments indicate that cell cytoplasm can exhibit both elastic and viscous character...
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Open AccessUBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
Ubiquilin-4 (UBQLN4), a member of the ubiquilin family, has received limited attention in cancer research to date. Here, we investigated for the first time the functional role and mechanism of UBQLN4 in non-sm...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Und...
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A multi-source heterogeneous medical data enhancement framework based on lakehouse
Obtaining high-quality data sets from raw data is a key step before data exploration and analysis. Nowadays, in the medical domain, a large amount of data is in need of quality improvement before being used to...
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Bispecific BCMA/CD19 targeted CAR-T cell therapy forces sustained disappearance of symptoms and anti-acetylcholine receptor antibodies in refractory myasthenia gravis: a case report
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Open AccessLow friction under ultrahigh contact pressure enabled by self-assembled fluorinated azobenzene layers
Extensive efforts have been made to pursue a low-friction state with promising applications in many fields, such as mechanical and biomedical engineering. Among which, the load capacity of the low-friction sta...
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A review of ultrafast laser micro/nano fabrication: Material processing, surface/interface controlling, and devices fabrication
Ultrafast laser processing technology has offered a wide range of opportunities in micro/nano fabrication and other fields such as nanotechnology, biotechnology, energy science, and photonics due to its contro...
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Article
Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment
The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic unresolved inflammation and overproduction of reactive oxygen species (ROS) being major drivers of plaque progression. Nan...
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Article
Stretchable continuous p-n alternating thermoelectric fibers for energy harvesting and sensing devices
The increased human demand for an intelligent life puts forward a great requirement for lightweight, stretchable, and comfort sensing and energy harvesting devices. Stretchable thermoelectric fiber becomes ver...
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Tool wear prediction based on a fusion model of data-driven and physical models in the milling process
Precision tool wear prediction in the milling process is crucial in enhancing product quality and machining efficiency. Both data-driven models and physical models are vital for indirect tool wear prediction. ...
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Open AccessMinimally invasive surgeries for spontaneous hypertensive intracerebral hemorrhage (MISICH): a multicenter randomized controlled trial
Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical methods for treating ICH. Unfortunately, thus far, no specific surgical method has been...
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Open AccessHealth economics study of paliperidone palmitate in the treatment of schizophrenia: a 12-month cohort study
To analyze the economic benefits of paliperidone palmitate in the treatment of schizophrenia.
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Open AccessCorrection: Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
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Effects of different biogas slurry application patterns on nitrogen and phosphorus losses in a paddy field
Biogas slurry, as a substitute for chemical fertilizers, is usually applied according to the needs of biogas slurry to be consumed at onetime. This poses a great risk of short-term nutrient overload in soils, ...
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Open AccessSRSF9 promotes cell proliferation and migration of glioblastoma through enhancing CDK1 expression
Glioblastoma (GBM) is a highly aggressive and prevalent brain tumor that poses significant challenges in treatment. SRSF9, an RNA-binding protein, is essential for cellular processes and implicated in cancer p...
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Open AccessSex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure
Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specific effect and underlying mechanisms remain unclear.
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Article
Evolutionary mechanism and frequency response of graphite electrode at extreme temperatures
The battery management system is employed to monitor the external temperature of the lithium-ion battery in order to detect any potential overheating. However, this outside–in detection method often suffers fr...
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Anti-asthmatic Substances in the Chinese Herbal Formulation Huagai San Based on In Vitro and In Vivo Analysis and Network Pharmacology
“Huagai san,” a Chinese classical herbal formulation, has been used for nearly 50 years to treat various conditions including bronchial asthma owing to its definite efficacy. It represents one of the few curre...
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Open AccessSmall extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here ...