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Article
Open AccessRandom survival forest for predicting the combined effects of multiple physiological risk factors on all-cause mortality
Understanding the combined effects of risk factors on all-cause mortality is crucial for implementing effective risk stratification and designing targeted interventions, but such combined effects are understud...
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Article
Open AccessMidbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice
The potential brain mechanism underlying resilience to socially transferred allodynia remains unknown. Here, we utilize a well-established socially transferred allodynia paradigm to segregate male mice into pa...
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Article
Open AccessConsensus holistic virtual screening for drug discovery: a novel machine learning model approach
In drug discovery, virtual screening is crucial for identifying potential hit compounds. This study aims to present a novel pipeline that employs machine learning models that amalgamates various conventional s...
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Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
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Article
Improving methane production from hydrogenogenic effluent with magnetic leaf biochar
Magnetic biochar is a potential economical additive for anaerobic digestion. To better understand the possible role of magnetic biochar on methanization performance, the effect of magnetic biochar on anaerobic...
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Article
Open AccessIdentification of immune-associated biomarker for predicting lung adenocarcinoma: bioinformatics analysis and experiment verification of PTK6
Abnormal expression of protein tyrosine kinase 6 (PTK6) has been proven to be involved in the development of gynecological tumors. However, its immune-related carcinogenic mechanism in other tumors remains unc...
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Article
Open AccessGenome assembly of a symbiotic balantidia (Balantidium ctenopharyngodoni) in fish hindgut
Balantidium ctenopharyngodoni is identified as the sole ciliate species that exclusively resides within the hindgut of grass carp with high prevalence and intensity. In this study, the successful cultivation of B...
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Article
Drainage-Driven Loss of Carbon Sequestration of a Temperate Peatland in Northeast China
Drainage is known to reduce carbon sequestration in peatlands, but its effect on the stability of carbon pool and changes in recalcitrant organic carbon fractions remain relatively unknown, especially in tempe...
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Open AccessInteractions between Balantidium ctenopharyngodoni and microbiota reveal its low pathogenicity in the hindgut of grass carp
Hosts, parasites, and microbiota interact with each other, forming a complex ecosystem. Alterations to the microbial structure have been observed in various enteric parasitic infections (e.g. parasitic protist...
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Article
One-step synthesis of dual-ligand 2D conductive metal-organic framework for high-performance lithium storage
Two-dimensional conductive metal-organic frameworks (2D c-MOFs) are emerging as promising electrode materials for lithium-ion batteries (LIBs). However, 2D c-MOFs with binary redox-active organic ligands are r...
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Article
Open AccessDNA methylation-activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma
Altered DNA methylation is a crucial epigenetic event in hepatocellular carcinoma (HCC) development and progression. Through methylation-transcriptomic analysis, we identified a set of sixty potential DNA meth...
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Article
Open AccessThe energy metabolism of Balantidium polyvacuolum inhabiting the hindgut of Xenocypris davidi
Anaerobic parasitic ciliates are a specialized group of ciliates that are adapted to anoxic and oxygen-depleted habitats. Among them, Balantidium polyvacuolum, which inhabits the hindgut of Xenocyprinae fishes, h...
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Article
Open AccessA thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering
Thermophilic cell factories have remarkably broad potential for industrial applications, but are limited by a lack of genetic manipulation tools and recalcitrance to transformation. Here, we identify a thermop...
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Article
Recent advances in metal-organic frameworks for oxygen evolution reaction electrocatalysts
The anodic oxygen evolution reaction (OER) can be combined with various cathodic reactions to enable the electrochemical synthesis of diverse chemicals and fuels, particularly in water electrolysis for hydroge...
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Article
Water retention behaviours of intact and recompacted loess exposed to multiple wetting-drying cycles
Wetting-drying cycles of weathering loading frequently lead to failure of infrastructures in loess regions, China. Water retention behaviours of loess are key information for capturing the physical causes of l...
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Article
Adaptive Fuzzy Finite Time Prescribed Performance Control for Long Stroke Hybrid Robots
This paper focus on the problem of finite-time trajectory tracking control of long stroke hybrid robots with uncertain system parameters and external disturbances. A system filtering prescribed performance bac...
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First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial
To explore targeted treatment options in patients with non-small-cell lung cancer (NSCLC) with rare genetic mutations in the context of a patient-centric clinical trial, we initiated, in parallel, a phase 2 ad...
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Article
Open Access3D hierarchical graphene matrices enable stable Zn anodes for aqueous Zn batteries
Metallic zinc anodes of aqueous zinc ion batteries suffer from severe dendrite and side reaction issues, resulting in poor cycling stability, especially at high rates and capacities. Herein, we develop two thr...
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Article
Open AccessThe direct prognosis comparison of 125I low-dose-rate brachytherapy versus laparoscopic radical prostatectomy for patients with intermediate-risk prostate cancer
This study aims to compare the clinical outcomes after performing radical prostatectomy (RP) or low-dose-rate brachytherapy (LDR) for patients with intermediate-risk prostate cancer (IRPC).
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Article
Far infrared properties of OH megamaser host galaxies
The hosts of OH megamaser (OHM) are luminous infrared galaxies (LIRGs), in fact 1/3 of them are ultra-luminous infrared galaxies (ULIRGs), which imply that OHM phenomena should be related to the infrared radia...
