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    Article

    Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway

    Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy. Previous evidence suggests that puera...

    Ning Hou, Yin Huang, Shao-ai Cai, Wen-chang Yuan, Li-rong Li in Acta Pharmacologica Sinica (2021)

  2. Article

    C-reactive protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-κB activation

    The receptor for advanced glycation end-products (RAGE) plays an important role in development of atherosclerosis, and C-reactive protein (CRP) has been found to stimulate its expression in endothelial cells. ...

    Yun Zhong, Chuan-fang Cheng, Yi-zhi Luo, Chao-wei Tian in Acta Pharmacologica Sinica (2015)

  3. Article

    Erratum to: UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes

    Cheng-Feng Luo, Bin Cai, Ning Hou, Mu Yuan, Shi-Ming Liu, Hong Ji in Archives of Toxicology (2012)

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    Article

    UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes

    Puerarin has multiple pharmacological effects and is widely prescribed for patients with cardiovascular diseases, including hypertension, cerebral ischemia, myocardial ischemia, diabetes mellitus, and arterios...

    Cheng-Feng Luo, Bin Cai, Ning Hou, Mu Yuan, Shi-Ming Liu, Hong Ji in Archives of Toxicology (2012)